null - FindTrial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2004-004721-10-GB

Enrollment

Registered

2005-04-18

Start date

2005-05-25

Completion date

Unknown

Last updated

2019-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Proximal femoral fracture

Interventions

Trade Name: Diprivan 1% Product Name: Diprivan 1% Pharmaceutical Form: Emulsion for injection Trade Name: Sevoflurane Product Name: Sev

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients =75 years old undergoing repair of proximal femoral fracture under general anaesthesia. Informed consent to participate (written and witnessed). Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) no F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Previous history of malignant hyperthermia or adverse reaction to inhalation anaesthetics or propofol were excluded. BMI >35 kg m23) Patients unable to give informed consent.

Design outcomes

Primary

Measure	Time frame
Main Objective: Main objective : There is a null hypothesis for the main outcome measure. It is anticipated that there will be no difference in the percentage change of mean arterial pressure (MAP) relative to baseline between elderly patients receiving co-induction of anaesthesia with propofol and sevoflurane (Group P+S), and elderly patients receiving induction with sevoflurane alone (Group S). ; Secondary Objective: Secondary objectives :To investigate whether there are any differences in elderly patients' perceptions of induction between Group P+S and Group S.To investigate whether there are any differences in the duration of the induction process between Group P+S and Group S. (Time to dropping weight and time to insertion of Laryngeal Mask Airway (LMA)).To investigate whether there are any differences in induction events between Group P+S and Group S. i.e. coughing, breath-holding, laryngospasm, movement of limb or excessive salivation. Graded as mild, moderate, severe [6].To investigate whether there are any differences in percentage change in cardiac output relative to baseline between Group P+S and Group S, measured by non-invasive trans-sternal Doppler. ;Primary end point(s): Percentage change of mean arterial pressure (MAP) relative to baseline.	—

Measure

Time frame

Main Objective: Main objective : There is a null hypothesis for the main outcome measure. It is anticipated that there will be no difference in the percentage change of mean arterial pressure (MAP) relative to baseline between elderly patients receiving co-induction of anaesthesia with propofol and sevoflurane (Group P+S), and elderly patients receiving induction with sevoflurane alone (Group S). ; Secondary Objective: Secondary objectives :To investigate whether there are any differences in elderly patients' perceptions of induction between Group P+S and Group S.To investigate whether there are any differences in the duration of the induction process between Group P+S and Group S. (Time to dropping weight and time to insertion of Laryngeal Mask Airway (LMA)).To investigate whether there are any differences in induction events between Group P+S and Group S. i.e. coughing, breath-holding, laryngospasm, movement of limb or excessive salivation. Graded as mild, moderate, severe [6].To investigate whether there are any differences in percentage change in cardiac output relative to baseline between Group P+S and Group S, measured by non-invasive trans-sternal Doppler. ;Primary end point(s): Percentage change of mean arterial pressure (MAP) relative to baseline.

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Countries

United Kingdom

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026