Pillot randomised controlled trial of antidepressant switching for treatmetn-refractory depression in primary care - SWITCh study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

EU CTR

Registry ID

EUCTR2004-004029-87-GB

Enrollment

100

Registered

2005-06-28

Start date

2005-01-24

Completion date

Unknown

Last updated

2019-11-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression

Interventions

Trade Name: Any antidepressant medication currently licensed in the UK Pharmaceutical Form:

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Age 18 years and over; a score=13 on Hamilton Rating Scale for Depression; a score of =9 on the Beck Depression Inventory; compliance with a selective serotonin re-uptake inhibitor for a minimum of 4 weeks. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) F.1.3.1 Number of subjects for this age range

Exclusion criteria

Exclusion criteria: Age <18 years; temporary GP registration; psychotic illness; suicidal patients; currently receiving psychological therapy or being managed by specialist services; pregnant

Design outcomes

Primary

Measure	Time frame
Main Objective: To determine the feasibility of conducting a randomised controlled trial to determine the clinical effectiveness of switching an antidepressant medicationto another from a different antidepressant class in primary care patinets with depression who have failed to respond to the initial antidepressant;Secondary Objective: To explore whether (i) demographic variables, social adversity, life events, physical health and diability are associated with outcome (ii) patient and doctor beliefs about depression and antidepressant medicationare associarted with outcome;Primary end point(s): 4-6 weeks of treatment in either arm of the trial.	—

Measure

Time frame

Main Objective: To determine the feasibility of conducting a randomised controlled trial to determine the clinical effectiveness of switching an antidepressant medicationto another from a different antidepressant class in primary care patinets with depression who have failed to respond to the initial antidepressant;Secondary Objective: To explore whether (i) demographic variables, social adversity, life events, physical health and diability are associated with outcome (ii) patient and doctor beliefs about depression and antidepressant medicationare associarted with outcome;Primary end point(s): 4-6 weeks of treatment in either arm of the trial.

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Countries

United Kingdom

Outcome results

None listed

Source: EU CTR (via WHO ICTRP) · Data processed: Feb 4, 2026