Fevers in childhood not asscoaited with severe disease in the immunocompenetent or fever in the immunocompromised host.
Conditions
Interventions
Trade Name: Paracetamol
Product Name: Paracetamol
Pharmaceutical Form: Syrup
Trade Name: Ibuprofen
Product Name: Ibuprofen
Sponsors
None listed
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: · Age between 6 months and 16 years old · Attending the Children’s Emergency Department of Bristol Royal Hospital for Children · A fever of 38.0 oC or above by tympanometric thermometer · Written consent signed Are the trial subjects under 18? yes Number of subjects for this age range: F.1.2 Adults (18-64 years) F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Severe or life threatening infection · Children admitted directly to the resuscitation area by ambulance due to the severity of their condition, or those transferred there following initial clinical assessment. Prior administration of study medication: · Paracetamol administered within the last six hours · Ibuprofen administered within the last six hours Current contraindication to either medicine: · Allergy to either ibuprofen or paracetamol · Haematemesis, haematochezia or melaena · Acute jaundice · Likely dehydration as defined by more than four episodes of diarrhoea or vomiting in the last 24 hours · Cellulitis or other spreading skin infection · Suspected chicken pox · Taking warfarin or heparin or known coagulopathy Chronic illness likely to interfere with drug metabolism · Known chronic kidney disease · Known chronic liver disease Immunosupression · Known primary immunodeficiency or HIV infection · Current treatment with chemotherapy or radiotherapy · Organ or bone marrow transplant recipient · On immunosuppressive therapy either currently or in the last three months (ie daily oral steroids for longer than two weeks, or other immunosuppressive agent)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: To test the efficacy of a combined dose of ibuprofen and paracetamol at reducing fever in children;Secondary Objective: If discharged from hospital, time spent in the department;Primary end point(s): · The child’s temperature one hour after study antipyretics. | — |
Countries
United Kingdom
Outcome results
None listed