Healthy volunteers
Conditions
Interventions
Trade Name: lidocaine 0.5%
Product Name: lidocaine 0.5%
Pharmaceutical Form: Injection*
Trade Name: lidocaine 2%
Product Name: lidocaine 2%
Pharmaceutical Form: Injection*
Trade Name: chirocaine 0.2
Sponsors
Research & Innovation Services, University of Dundee
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Healthy, male. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range ;Inclusion criteria: Healthy, male. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18-64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range
Exclusion criteria
Exclusion criteria: Smokers, currently receiving medication, known hypersensitivity to amide local anaesthetics, history of vascular disease, history of hypersensitive responses such as hay fever and asthma. ;Exclusion criteria: Smokers, currently receiving medication, known hypersensitivity to amide local anaesthetics, history of vascular disease, history of hypersensitive responses such as hay fever and asthma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main Objective: Surgically-induced inflammation is a significant source of post-operative pain. Clinical and experimental observation indicates that local anaesthetics, in addition to their analgesic properties, might play a role in reducing inflammation after surgery. Furthermore, there is evidence from animal studies that local anaesthetics have an inhibitory effect on the action of inflammatory mediators such as bradykinin and substance P. The aim of our study is to investigate the inhibitory effects of the local anaesthetics lignocaine, levobupivacaine and ropivacaine on the inflammatory flare in skin blood flow produced by intradermal injection of bradykinin and substance P. ;Secondary Objective: ;Primary end point(s): Cutaneous blood flow responses to intradermal injection of bradykin and substance P.;Main Objective: Surgically-induced inflammation is a significant source of post-operative pain. Clinical and experimental observation indicates that local anaesthetics, in addition to their analgesic properties, might play a role in reducing inflammation after surgery. Furthermore, there is evidence from animal studies that local anaesthetics have an inhibitory effect on the action of inflammatory mediators such as bradykinin and substance P. The aim of our study is to investigate the inhibitory effects of the local anaesthetics lignocaine, levobupivacaine and ropivacaine on the inflammatory flare in skin blood flow produced by intradermal injection of bradykinin and substance P. ;Secondary Objective: ;Primary end point(s): Cutaneous blood flow responses to intradermal injection of bradykin and substance P. | — |
Countries
United Kingdom
Contacts
Public Contact; ;
;
Outcome results
None listed