I71.4
Conditions
Interventions
Group 1: Investigation of the AAA-specific pathogenic relevance of platelet activation states, erythrocyte-associated effects, and their relationship to the size and/or progression of abdominal aortic
Sponsors
Universitätsklinikum Düsseldorf
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients presenting for blood donation at the blood bank who have provided informed consent for the use of their blood samples for experimental research purposes as part of the ATLaNtA study (2018-140_2KFogU: “Potential activation mechanisms and interactions of platelets in degenerative diseases of the liver, brain, and aorta – ATLaNtA study”). Patients with AAA/TAA fulfilling guideline-based indications for endovascular aneurysm repair (study cohort). Patients with AAA/TAA presenting for routine follow-up examinations at the vascular outpatient clinic. Patients with other atherosclerotic vascular diseases (excluding AAA/TAA), including peripheral arterial occlusive disease (PAOD) or carotid artery stenosis, presenting for routine follow-up examinations at the vascular outpatient clinic. Age =18 years. Technically feasible blood collection. Written informed consent.
Exclusion criteria
Exclusion criteria: • Lack of a declaration of consent • Psychiatric disorders and the resulting legal incapacity • Known blood clotting disorders • Known genetic platelet disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of the association and/or correlation between AAA/TAA size and/or disease progression and platelet activation status as well as erythrocyte-specific prothrombotic propensity. Study parameters will be reassessed every six months based on the collected analyses. | — |
Secondary
| Measure | Time frame |
|---|---|
| Identification of platelet- and/or erythrocyte-specific markers as potential biomarkers for abdominal and thoracic aortic aneurysm (AAA/TAA). | — |
Countries
Germany
Contacts
Public ContactKim Krott
Universitätsklinikum Düsseldorf
Outcome results
None listed