Project Title: Investigation of Inflammatory Mechanisms in Skin Cells of Women and Men

Project Title: Investigation of Inflammatory Mechanisms in Skin Cells of Women and Men - Mechanisms in Skin Cells

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00041140

Enrollment

Registered

2026-07-28

Start date

2026-08-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

L40.9

Interventions

Group 1: Included patient groups: Patients > 18 years of age Study design: 1. Obtaining written informed consent from patients (see Patient Information). 2. The skin tissue (eyelid) used for this stu

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Psoriasis Eye Surgery

Exclusion criteria

Exclusion criteria: <18 Y.

Design outcomes

Primary

Measure	Time frame
Isolation of primary human keratinocytes to investigate differential signaling pathways in men and women. Collection of inflammation, gene expression, lipidome, and metabolome data in primary keratinocytes from skin samples of male and female patients. The cells are incubated with and without inflammatory stimulation for varying periods of time, processed, and then subjected to molecular biological and biochemical analyses. The endpoint is the identification of new or different inflammatory mechanisms in male and female patients.	—

Measure

Time frame

Isolation of primary human keratinocytes to investigate differential signaling pathways in men and women. Collection of inflammation, gene expression, lipidome, and metabolome data in primary keratinocytes from skin samples of male and female patients. The cells are incubated with and without inflammatory stimulation for varying periods of time, processed, and then subjected to molecular biological and biochemical analyses. The endpoint is the identification of new or different inflammatory mechanisms in male and female patients.

—

Secondary

Measure	Time frame
Correlation of molecular data with patient characteristics (particularly gender).	—

Countries

Germany

Contacts

Public ContactYaroslava Wenner

Klinik für Augenheilkunde - Universitätsklinikum Frankfurt am Main

yaroslava.wenner@unimedizin-ffm.de+4969630183493

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 10, 2026