loss of skin quality in healthy skin
Conditions
Interventions
Group 1: NEAUVIA Hydro Deluxe (HACaHA) – 2,5 mL, one side of the face
Group 2: Profhilo® (non-cross-linked HA) – 2 mL, contralateral side of the face
Sponsors
Universität Hamburg Fakultät für Mathematik, Informatik und Naturwissenschaften (MIN) Institut für Biochemie und Molekularbiologie Fachbereich Kosmetikwissenschaft
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Female sex Age between 18 and 65 years (inclusive) Generally good state of health Understanding of and agreement to the study procedures Sufficient time availability for the duration of the study No inflammatory skin conditions in the treatment area Self-assessed skin quality score = 50% on the questionnaire Expert rating of at least "mild" (1) at rest and "moderate" (2) at maximum smiling, at V1 SASSQ rating with at least three of six categories scoring = 2 ("moderate"), at V1
Exclusion criteria
Exclusion criteria: Pregnancy, breastfeeding, or planned pregnancy / egg donation Use or topical application of medications affecting skin quality (e.g., retinoids) Use of anticoagulants or anti-inflammatory drugs Clinically relevant skin, autoimmune, or collagen diseases Smoking (current or within the last 6 months) Previous invasive or minimally invasive aesthetic treatments in the study area within the last 12 months Permanent fillers and implants in the study area Excessive UV exposure, current or past Tattoos or significant scars on the face Participation in another clinical study within the last 30 days Contact of the study area with substances, skincare products, or cleaning products, as well as water, within the last 6 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of biophysical parameters of skin quality—including hydration, transepidermal water loss (TEWL), elasticity, skin thickness/density, erythema and melanin indices, sebum levels, and surface texture—before and after treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Self-assessment, satisfaction, tolerability, SASSQ/GAIS expert ratings, wrinkle depth, and photographic evaluation | — |
Countries
Germany
Contacts
Public ContactKristina Carmen Bernhöft
Universität Hamburg Fachbereich Chemie Arbeitsgruppenleitung AG Kerscher Institut für Biochemie und Molekularbiologie
Outcome results
None listed