Molecular and immunological mechanisms of local and systemic inflammatory responses in periodontitis: the role of immunosenescence in disease progression and treatment response

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00041048

Enrollment

120

Registered

2026-07-22

Start date

2026-09-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K05.3

Interventions

Group 1: All enrolled participants receive guideline-based periodontal therapy according to the current German periodontal treatment guideline. The study includes four assessment time points (baseline

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Written informed consent Diagnosis of periodontitis (Stage I or Stage III/IV according to the current classification) Planned guideline-based periodontal treatment at the Department of Conservative Dentistry and Periodontology, University Hospital Cologne Willingness to participate in all scheduled study visits and follow-up examinations

Exclusion criteria

Exclusion criteria: Age <18 years No written informed consent No indication for periodontal treatment Inability to understand the study or provide informed consent Pregnancy or breastfeeding (due to the study-related blood sampling) Acute systemic infections or other medical conditions that, in the opinion of the investigators, may interfere with study participation or interpretation of the results

Design outcomes

Primary

Measure	Time frame
Primary outcome: Change in interleukin-6 (IL-6) concentrations in gingival crevicular fluid (GCF) and EDTA plasma between baseline and follow-up visits (AIT, BEV, UPT). Assessment: Baseline, AIT, BEV and UPT. Assessment method: Quantification using a bead-based multiplex immunoassay (Luminex/NULISA or equivalent multiplex platform).	—

Secondary

Measure	Time frame
Secondary outcomes: Changes in local and systemic inflammatory and SASP markers. Characterization of local cellular senescence markers (cell-cycle arrest and DNA damage response) in gingival/granulation tissue. Changes in the composition of the supra- and subgingival microbiome. Changes in clinical periodontal parameters (PPD, CAL, BoP, plaque index). Association between age, immunosenescence and response to periodontal therapy.	—

Measure

Time frame

Secondary outcomes: Changes in local and systemic inflammatory and SASP markers. Characterization of local cellular senescence markers (cell-cycle arrest and DNA damage response) in gingival/granulation tissue. Changes in the composition of the supra- and subgingival microbiome. Changes in clinical periodontal parameters (PPD, CAL, BoP, plaque index). Association between age, immunosenescence and response to periodontal therapy.

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Countries

Germany

Contacts

Public ContactLi Sun

Universitätsklinikum Köln Poliklinik für Zahnerhaltung und Parodontologie

li.sun1@uk-koeln.de0221 478 98551

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 10, 2026