Weight Development in Children Undergoing Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: A Retrospective Analysis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00041010

Enrollment

400

Registered

2026-07-16

Start date

2022-03-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Z94.8 C80 C96 D47 D56 D57

Interventions

Group 1: Retrospective observational cohort of children and adolescents undergoing allogeneic or autologous hematopoietic stem cell transplantation. Medical records are retrospectively reviewed to ass

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who underwent allogeneic or autologous hematopoietic stem cell transplantation at the University Children's Hospital Tübingen between January 1, 2013 and December 31, 2021.

Exclusion criteria

Exclusion criteria: Patients with permanently impaired oral food intake prior to hematopoietic stem cell transplantation (e.g. dependence on gastrostomy feeding), known congenital or acquired gastrointestinal malformations or previous gastrointestinal resection, and pre-existing inflammatory bowel disease.

Design outcomes

Primary

Measure	Time frame
Association between pre-transplant nutritional status (body mass index [BMI] percentile) and changes in BMI percentile up to day +200 after hematopoietic stem cell transplantation and the occurrence of transplant-related complications. Transplant-related complications include acute and chronic graft-versus-host disease (GvHD), sinusoidal obstruction syndrome (SOS/VOD), mucositis, bacterial, viral and invasive fungal infections, BK virus-associated cystitis, and graft failure. Outcomes are retrospectively assessed using pseudonymized routine clinical data from hospital admission until day +200 after HSCT.	—

Measure

Time frame

Association between pre-transplant nutritional status (body mass index [BMI] percentile) and changes in BMI percentile up to day +200 after hematopoietic stem cell transplantation and the occurrence of transplant-related complications. Transplant-related complications include acute and chronic graft-versus-host disease (GvHD), sinusoidal obstruction syndrome (SOS/VOD), mucositis, bacterial, viral and invasive fungal infections, BK virus-associated cystitis, and graft failure. Outcomes are retrospectively assessed using pseudonymized routine clinical data from hospital admission until day +200 after HSCT.

—

Secondary

Measure	Time frame
Overall survival, transplant-related mortality, time to engraftment, changes in body weight, height and BMI percentiles during follow-up, duration of hospitalization, and the frequency of microbiological pathogens detected in stool, blood and urine samples, including their association with nutritional status and transplant-related complications.	—

Countries

Germany

Contacts

Public ContactMichaela Döring

Universitätsklinikum Tübingen

michaela.doering@med.uni-tuebingen.de+497071290

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 10, 2026