Z94.8 C80 C96 D47 D56 D57
Conditions
Interventions
Group 1: Participants receive a structured trampoline-based exercise program instead of standard physiotherapy during hospitalization for hematopoietic stem cell transplantation. The intervention incl
Sponsors
Universitätsklinikum Tübingen
Eligibility
Sex/Gender
All
Age
5 Years to 22 Years
Inclusion criteria
Inclusion criteria: Hematopoietic stem cell transplantation for the treatment of a malignant or non-malignant disease Independent ambulation without the use of assistive devices at hospital admission Karnofsky Performance Status =70% at the time of study enrollment Written informed consent from the participant and, where applicable, the participant's legal guardian
Exclusion criteria
Exclusion criteria: Congenital malformation syndromes (e.g., trisomy 21) Fractures or an increased risk of fractures Severe neurological or cognitive impairment preventing participation in the exercise program or study assessments Severe coagulation disorders or other medical contraindications to physical exercise
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in physical performance and mobility from baseline to follow-up assessments up to day +200 after hematopoietic stem cell transplantation, assessed using standardized functional performance tests (6-minute walk test, Timed Up and Go test) and muscle circumference measurements (quadriceps femoris and triceps surae muscles). | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in health-related quality of life, psychosocial distress, motivation, and affective state from baseline to follow-up assessments up to day +200 after hematopoietic stem cell transplantation, assessed using the KINDL®, PO-BaDo, FAM, and Self-Assessment Manikin (SAM). Changes in serum cortisol concentrations are additionally evaluated. | — |
Countries
Germany
Contacts
Public ContactMichaela Döring
Universitätsklinikum Tübingen
Outcome results
None listed