persistent atrial fibrillation
Conditions
Interventions
Group 1: Patients between 18 and 85 years of age planned for a first ablation for persistent atrial fibrillation or having received one previous ablation with sole isolation of the pulmoray veins.
Sponsors
TUM Klinikum Deutsches Herzzentrum
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: - Patient is able and willing to comply with the protocol requirements - Written informed consent - Planned first ablation for persistent atrial fibrillation or one previous ablation with sole isolation of the pulmonary veins (no further atrial substrate modification)
Exclusion criteria
Exclusion criteria: - Previous left-atrial substrate modification - Previous cardiac surgery potentially alternating the atrial substrate - Paroxysmal or permanent atrial fibrillation - Any cardiac ablation less than 2 months ago
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reliable and reproducible identification of presence , extent and distribution of abnormal electrogram patterns during atrial fibrillation including abnormal peak frequency, voltage, conduction velocity, dispersions, near-field electrograms and emphasis mapping. | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) comparison of the identified regions between patients with prior AF ablation and without prior AF ablation, (2) association between identified substrate and arrhythmia recurrence during follow-up and (3) analysis of additional signal characteristics (activation vectors, fractionation, repetitiveness, electrogram duration, peak frequency gradient, comparison with currently available mapping algorithms) in identified regions. | — |
Countries
Germany
Contacts
Public ContactIsabel Deisenhofer
TUM Klinikum Deutsches Herzzentrum
Outcome results
None listed