Skeletal Phenotyping in Complex Musculoskeletal Diseases: A Retrospective Analysis of Bone Density, Microarchitecture and Structural Parameters

Skeletal Phenotyping in Complex Musculoskeletal Diseases: A Retrospective Analysis of Bone Density, Microarchitecture and Structural Parameters - SPECTRA Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00040816

Enrollment

200

Registered

2026-06-30

Start date

2026-06-29

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complex musculoskeletal diseases are conditions that affect the bones, joints, muscles, or tendons and are often associated with changes in bone strength or bone metabolism. These include, for example, rare bone diseases (such as osteogenesis imperfecta, X-linked hypophosphatemia, or hypophosphatasia), osteoporosis, inflammatory or genetic skeletal disorders, and other diseases affecting the musculoskeletal system.

Interventions

Group 1: To characterize skeletal phenotypes in patients with complex musculoskeletal diseases based on bone density, microarchitecture, and structural parameters through retrospektive patient data a

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with a clinically and/or genetically confirmed complex musculoskeletal disease. Availability of DXA examinations performed as part of routine clinical care with analyzable datasets for bone mineral density (BMD), trabecular bone score (TBS), and/or structural bone parameters (3D-Shaper) from 2023 on. Availability of complete baseline clinical data (e.g., age, sex, and diagnosis).

Exclusion criteria

Exclusion criteria: Incomplete or non-analyzable DXA imaging data. Missing essential clinical data required for the planned analyses.

Design outcomes

Primary

Measure	Time frame
To characterize skeletal phenotypes in patients with complex musculoskeletal diseases based on bone density, microarchitecture, and structural parameters	—

Secondary

Measure	Time frame
• To describe the distribution and variability of areal bone mineral density in patients with complex musculoskeletal diseases. • To evaluate trabecular bone microarchitecture and determine the prevalence of altered trabecular structure in patients with complex musculoskeletal diseases. • To analyze structural bone parameters, including cortical thickness, cortical surface bone density, and trabecular volumetric bone density. • To explore associations between DXA-derived skeletal Imaging parameters and biochemical characteristics of complex musculoskeletal diseases.	—

Measure

Time frame

• To describe the distribution and variability of areal bone mineral density in patients with complex musculoskeletal diseases. • To evaluate trabecular bone microarchitecture and determine the prevalence of altered trabecular structure in patients with complex musculoskeletal diseases. • To analyze structural bone parameters, including cortical thickness, cortical surface bone density, and trabecular volumetric bone density. • To explore associations between DXA-derived skeletal Imaging parameters and biochemical characteristics of complex musculoskeletal diseases.

—

Countries

Germany

Contacts

Public ContactLothar Seefried

Universitätsklinikum Würzburg Osteologie / Kliniksche Studieneinhei

lothar.seefried@klh.de09318033575

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 10, 2026