B50 B51 B52 B53 B54
Conditions
Interventions
Group 1: Participants with a migration background, defined as having spent the majority of their childhood up to the age of five years in a malaria-endemic area. In addition, participants must have st
Sponsors
Bernhard-Nocht-Institut für Tropenmedizin
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - Migration background, defined as having lived for at least the majority of early childhood up to the age of 5 in a malaria-endemic area - At least one stay in a malaria-endemic country within the last 15 years.
Exclusion criteria
Exclusion criteria: none
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of the prevalence of asymptomatic Plasmodium spp. infections among VFR travellers and migrants from malaria-endemic countries. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Identification of demographic, clinical, and laboratory factors associated with an increased likelihood of asymptomatic parasitaemia. - Determination of the median duration of chronic parasitaemia following departure from a malaria-endemic area. Exploratory endpoints: - Quantitative and qualitative analysis of malaria-specific antibody responses in asymptomatic P. falciparum-infected participants compared with uninfected participants and patients with acute malaria. - Analysis of the temporal persistence of malaria-specific immune responses in the absence of ongoing exposure. - Identification and characterization of the virulence and persistence mechanisms of P. falciparum in the context of human infections. - Characterization of malaria-specific CD4? T-cell responses in asymptomatic P. falciparum-infected participants compared with uninfected participants and patients with acute malaria. - Characterization of malaria-specific memory B-cell responses in asymptomatic P. falciparum-infected participants compared with uninfected participants and patients with acute malaria. - Characterization of innate immune responses in asymptomatic P. falciparum-infected participants compared with uninfected participants and patients with acute malaria. - Characterization of the distribution of innate immune cell populations according to travel behaviour, diet, and physical activity. - Seroprevalence of parasitic infections. - Seroprevalence of vaccine-preventable diseases. - Assessment of immunization status. | — |
Countries
Germany
Contacts
Public ContactJohannes Mischlinger
Bernhard-Nocht-Institut für Tropenmedizin
Outcome results
None listed