Espresso for the Reduction of Delayed Gastric Emptying After Pancreatoduodenectomy: RISTRETTO

Espresso for the Reduction of Delayed Gastric Emptying After Pancreatoduodenectomy: RISTRETTO - RISTRETTO

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00040799

Enrollment

138

Registered

2026-06-30

Start date

2026-07-20

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients scheduled for elective pancreatoduodenectomy for benign or malignant diseases

Interventions

Group 1: Intervention Group (Espresso) Participants receive 60 mL of espresso three times daily on postoperative days 1–3 (08:00 am, noon, and 4:00 pm

each ±45 minutes). The beverage is served at 52–62 °C and consumed within 10 minutes under the supervision of the study team. Consumption of additional caffeine-containing beverages is not permitted d

each ±45 minutes). The beverage is served at 52–62°C and consumed within 10 minutes under the supervision of the study team. Consumption of additional caffeine-containing beverages is not permitted du

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Scheduled partial pancreaticoduodenectomy for benign or malignant disease. Ability to understand the study procedures and comply with the study protocol. Written informed consent

Exclusion criteria

Exclusion criteria: Planned or performed arterial reconstruction or total pancreatectomy. Regular consumption of more than two cups of espresso per day. Intolerance to espresso. Congestive heart failure with a left ventricular ejection fraction (LVEF) 100 beats/min at rest). American Society of Anesthesiologists (ASA) physical status classification > III. Language barrier or cognitive impairment interfering with study participation

Design outcomes

Primary

Measure	Time frame
Occurrence of delayed gastric emptying (DGE) within 90 days following partial pancreaticoduodenectomy, classified according to the criteria of the International Study Group of Pancreatic Surgery (ISGPS)	—

Secondary

Measure	Time frame
Operative parameters (surgical approach, operative time, intraoperative blood loss), functional recovery (time to first flatus, first bowel movement, tolerance of solid food, use of laxatives or prokinetic agents), length of hospital stay, hospital readmission, reoperation rate, overall postoperative morbidity (Comprehensive Complication Index), postoperative pancreatic fistula (POPF), postpancreatectomy hemorrhage, chyle leak, bile leak, organ/space surgical site infections, occurrence of pancreatogenic diabetes mellitus, postoperative quality of recovery (QoR-15), and intervention-related safety outcomes (symptomatic gastroesophageal reflux, endoscopically confirmed peptic ulcer disease, and cardiac adverse events).	—

Measure

Time frame

Operative parameters (surgical approach, operative time, intraoperative blood loss), functional recovery (time to first flatus, first bowel movement, tolerance of solid food, use of laxatives or prokinetic agents), length of hospital stay, hospital readmission, reoperation rate, overall postoperative morbidity (Comprehensive Complication Index), postoperative pancreatic fistula (POPF), postpancreatectomy hemorrhage, chyle leak, bile leak, organ/space surgical site infections, occurrence of pancreatogenic diabetes mellitus, postoperative quality of recovery (QoR-15), and intervention-related safety outcomes (symptomatic gastroesophageal reflux, endoscopically confirmed peptic ulcer disease, and cardiac adverse events).

—

Countries

Germany

Contacts

Public ContactNuh N. Rahbari

Universitätsklinikum Ulm, Klinik für Allgemein- und Viszeralchirurgie

nuh.rahbari@uniklinik-ulm.de+4973150053501

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 10, 2026