F32.0 F32.1 F32.8 G35
Conditions
Interventions
Group 1: Patients with mild to moderate early-stage depressive symptoms, four-week treatment with transcutaneous vagus nerve stimulation
Sponsors
Edda und Helmut Laich Stiftung
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: • Mild to moderate depressive symptoms, acute depressive episode (including sleep disturbances) • (MS diagnosis) • If applicable, diagnosis of depression for no more than 4 years
Exclusion criteria
Exclusion criteria: • Use of psychiatric medications or sedative sleep aids • Severe visual impairment • Severe physical or other psychiatric conditions • Alcohol or drug dependence • Metal objects that are not compatible with MRI scans
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in depressive symptoms (External assessment using the Hamilton Depression Rating Scale weekly at t0, t1, t2, t3, and t4, t5; self-assessment using the BDI-II every two weeks at t0, t2, and t4, t5) | — |
Secondary
| Measure | Time frame |
|---|---|
| cortical activation, functional connectivity, sleep quality, quality of life, immune parameters | — |
Countries
Germany
Contacts
Public ContactFelix Bernhard
Klinik für Psychiatrie und Psychotherapie Philipps-Universität Marburg
Outcome results
None listed