Isolation of new periodontal-associated bacterial species using Culturomics - A comparison of microbiome analysis employing "Next Generation Sequencing (NGS)

Isolation of new periodontal-associated bacterial species using Culturomics - A comparison of microbiome analysis employing "Next Generation Sequencing (NGS) - Culturomics

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00040749

Enrollment

Registered

2026-07-02

Start date

2026-06-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

periodontitis

Interventions

Group 1: patients with periodontitis: supragingival samples Group 2: patients with periodontitis: subgingival samples

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1 tooth per patient with persisting probing pocket depth = 6 mm. Periodontal recall patients.

Exclusion criteria

Exclusion criteria: Systemic diseases, intake of antibiotics/antimycotics, compromised immune system, smoking, pregnancy/nursing, participation in other clinical studies.

Design outcomes

Primary

Measure	Time frame
Detection of periodontitis-associated microorganisms in subgingival or supragingival samples from subjects with periodontitis using culture/culturomics and sequencing/identification. After sample collection during oral/dental examination/treatment and successful cultivation/detection. Cultivation/culturomics and sequencing/identification (MALDI-TOF MS, 16S rRNA amplicon sequencing, shotgun metagenomic sequencing)	—

Measure

Time frame

Detection of periodontitis-associated microorganisms in subgingival or supragingival samples from subjects with periodontitis using culture/culturomics and sequencing/identification. After sample collection during oral/dental examination/treatment and successful cultivation/detection. Cultivation/culturomics and sequencing/identification (MALDI-TOF MS, 16S rRNA amplicon sequencing, shotgun metagenomic sequencing)

—

Countries

Germany

Contacts

Public ContactAli Al-Ahmad

Uniklinik Freiburg

ali.al-ahmad@uniklinik-freiburg.de+49 761 270-48940

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 10, 2026