Intensive care patients on mechanical ventilation, including those requiring prolonged ventilation and weaning from mechanical ventilation.
Conditions
Interventions
Group 1: Prospective observational study of adult critically ill patients on mechanical ventilation who are experiencing difficult weaning or severe acute respiratory distress syndrome (ARDS). As part
Sponsors
Universitätsklinikum Erlangen – Anästhesiologische Klinik
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Either a group requiring postoperative ventilation for >24 hours: a patient receiving postoperative ventilation or a patient with an expected ventilation duration of >24 hours Or patients with severe ARDS: Severe ARDS according to the Berlin definition (respiratory failure not due to cardiac failure or volume overload, acute onset, bilateral opacities, paO2/FiO2 <100) - Nasogastric esophageal pressure probe in place - Admission to a participating intensive care unit
Exclusion criteria
Exclusion criteria: - Pre-existing severe lung disease - Previous participation in this clinical trial (PreVent) - Exclusion from the trial based on a healthcare directive - Poor prognosis (death expected within the next few hours despite maximum therapy) - Pregnancy - The patient is institutionalized by court or administrative order
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subjective assessment of respiratory effort and patient-ventilator asynchrony by intensive care staff before and after presentation of the sEMG data. The assessment is conducted using a study-specific questionnaire during the early phase of spontaneous breathing and at the start of intermittent weaning. | — |
Secondary
| Measure | Time frame |
|---|---|
| System usability (System Usability Scale, SUS) and descriptive analysis of patient-ventilator asynchronies and potential surrogate parameters. | — |
Countries
Germany
Contacts
Public ContactRoland C. E. Francis
Universitätsklinikum Erlangen – Anästhesiologische Klinik
Outcome results
None listed