J96.00
Conditions
Interventions
Group 1: Intra-individual crossover design, in which all patients undergo two protocols in succession in randomised order.
In Protocol A, titration is performed in steps of 4 breaths/min each, beginn
Sponsors
Medizinische Hochschule Hannover
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Mechanical ventilation in intensive care unit
Exclusion criteria
Exclusion criteria: Risk of raised intracranial pressure, pregnancy, electrically active implants (pacemakers, implantable cardioverter-defibrillators), unstable spinal or thoracic injuries, BMI > 50, open skin lesions in the area of the electrode positions, drains or dressings that make correct electrode positioning impossible.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Center of Ventilation Measured during respiratory rate titration in both protocols Electrical impedance tomography measurement | — |
Secondary
| Measure | Time frame |
|---|---|
| Silent Spaces (%) and Global Inhomogeneity Index measured by electrical impedance tomography CO2 elimination (VCO2, ViCO2, VeCO2 measured by volumetric capnometry; PaCO2 by arterial blood gas analysis) Dead space (anatomical, physiological, alveolar) Transpulmonary pressure | — |
Countries
Germany
Contacts
Public ContactThomas Stueber
Medizinische Hochschule Hannover
Outcome results
None listed