venous congestion in the intensive care setting
Conditions
Interventions
Group 1: As study-related procedures, clinical routine data will first be collected and processed in pseudonymised form within the hospital in order to assess possible eligibility for study inclusion.
Sponsors
Universitätsklinikum Regesburg, Klinik für Anästhesiologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Admission to the intensive care unit - Arterial blood pressure monitoring - Invasive mechanical ventilation via endotracheal tube or tracheostomy tube - Deep sedation (RASS -3 to -5)
Exclusion criteria
Exclusion criteria: - History of spontaneous pneumothorax - Known pregnancy - Pre-existing Child C liver cirrhosis - Physical impairment, such as spinal instability, preventing passive leg raising - Insufficient ultrasound accessibility for data acquisition
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in the total VExUS score induced by modulation of positive end-expiratory pressure (PEEP) and by a preload manoeuvre (passive leg raise) at the time of the study visit. Assessment will be performed by ultrasound examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Exploratory analysis: renal function during the subsequent course of intensive care treatment. 2. Exploratory analysis: correlation of the measured parameters with laboratory markers of congestion, such as NT-proBNP, if available. 3. Exploratory analysis: correlation of echocardiographic parameters with PEEP level and the passive leg raise manoeuvre. | — |
Countries
Germany
Contacts
Public ContactMaximilian Käss
Universitätsklinikum Regensburg, Klinik für Anästhesiologie
Outcome results
None listed