biological aging processes
Conditions
Interventions
Group 1: Participants randomized to the intervention group will receive a 16-week endurance training program immediately following baseline testing (T0), which will be conducted at the Fitnessförderwe
Sponsors
Technische Universität Dortmund, Institut für Sport und Sportwissenschaft (Fakultät 16)
Eligibility
Sex/Gender
All
Age
40 Years to 64 Years
Inclusion criteria
Inclusion criteria: untrained (defined as less than 1 hour of endurance training per week over the past six months)
Exclusion criteria
Exclusion criteria: acute infections or orthopedic problems that make spiroergometric exercise testing impossible; smoking; BMI > 30; the presence of a pacemaker or an ongoing pregnancy, as these conditions make it impossible to perform bioimpedance analysis to assess body composition; insufficient knowledge of German, as this makes it impossible to complete the questionnaires; metabolic disorders such as diabetes mellitus; known cardiovascular diseases (uncontrolled arterial hypertension, coronary heart disease, heart failure, ...); known neurological or oncological diseases; tryptophan supplementation in the past 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| biological markers of aging (3-hydroxyanthranilic acid (3-HAA), metabolites of tryptophan metabolism, inflammatory biomarkers), “aging clocks” based on the plasma proteome, and the Immune Age Index (IMMAX) each before and after spiroergometric performance testing at T0 (baseline), T1 (post-intervention), T2 (follow-up) venous blood sample (4 heparin tubes à 9 mL, 1 EDTA tube à 2.6 mL, 2 serum tubes of 8 mL each; total 54.6 mL) and saliva samples (using Salivette®, Sarstedt, Germany) | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographic characteristics: age, gender, occupation T0 (Baseline) Self-administered questionnaires Demographic characteristics: use of hormonal contraceptives, chronic pre-existing conditions, allergies, regular medication use, regular use of dietary supplements, alcohol consumption, smoking habits, and drug use T0 (Baseline), T1 (Post-Intervention), T2 (Follow-Up) Self-administered questionnaires Anthropometric characteristics: Height, weight, waist and hip circumference T0 (Baseline), T1 (Post-Intervention), T2 (Follow-Up) Scale, measuring tape Body composition T0 (Baseline), T1 (Post-Intervention), T2 (Follow-Up) Bioelectrical impedance analysis (mBCA 525 seca gmbh & co. kg.) Handgrip strength measurement T0 (Baseline), T1 (Post-Intervention), T2 (Follow-Up) Hand dynamometer (Jamar Hydraulic Hand Dynamometer, Performance Health Supply Inc., Cedarburg, Wisconsin) Endothelial function T0 (Baseline), T1 (Post-Intervention), T2 (Follow-Up) Sonographic measurement of flow-mediated dilation of the brachial artery (Vivid iq v204, GE Healthcare GmbH, Düsseldorf) Chronotype T0 (Baseline) Chronotype questionnaire (D-MEQ) (Griefahn et al., 2001) Sleep quality T0 (Baseline), T1 (Post-intervention), T2 (Follow-up) Pittsburgh Sleep Quality Index (Buysse et al., 1989) Physical activity level T0 (Baseline), T1 (Post-intervention), T2 (Follow-up) Godin Leisure-Time Exercise Questionnaire (Godin & Shephard, 1985) and the Global Physical Activity Questionnaire Exercise physiology parameters: (sub)maximal performance, blood pressure, subjective perception of exertion T0 (Baseline), T1 (Post-intervention), T2 (Follow-up) for each spiroergometric performance assessment BORG scale (Borg, 1982) Exercise physiology parameters: heart rate, heart rate variability T0 (Baseline), T1 (Post-Intervention), T2 (Follow-Up) for each spiroergometric performance assessment ECG Exercise physiology parameters: oxygen uptake and carbon dioxide output, t | — |
Countries
Germany
Contacts
Public ContactNiklas Joisten
Technische Universität Dortmund, Institut für Sport und Sportwissenschaft (Fakultät 16)
Outcome results
None listed