coronary heart disease, coronary microvascular dysfunction
Conditions
Interventions
Group 1: Adult patients with a cardiovascular risk profile and a wide spectrum of comorbidities undergoing elective cardiac catheterization or an electrophysiological study.
Sponsors
Friede Springer Cardiovascular Reseach Center
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: invasive cardiac diagnostics Consent to participate
Exclusion criteria
Exclusion criteria: consent withdrawn, inability to consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the occurrence of MACE (major adverse cardiovascular events): stroke, myocardial infarction, and death. Follow-up of the study participants is planned for 10 years after enrollment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include, among others: - Coronary function measurements - Patient characterization using questionnaires to assess relevant risk factors - Standard laboratory parameters (incl. blood count, lipid parameters, renal retention markers, liver enzymes, natriuretic peptides, troponin, C-reactive protein, glucose metabolism) - Blood metabolites (mass spectrometry) - Proteome analyses (Olink, multiplex ELISA) - fecal analysis of gut microbial composition and metabolites - Genotyping, genome sequencing - Immune cell function in peripheral blood - Coagulation parameters and platelet function measurements - Urine metabolites | — |
Countries
Germany
Contacts
Public ContactMarco Witkowski
Friede Springer Cardiovascular Prevention Center @Charite Universitätsmedizin Berlin
Outcome results
None listed