Influence of supervised exercise therapy sessions during neoadjuvant chemotherapy on the number of viable tumor cells in patients with Ewing sarcoma or osteosarcoma

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00040658

Enrollment

150

Registered

2026-06-16

Start date

2026-02-05

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C40-C41

Interventions

Group 1: A total cohort of n = 250 patients is available for the retrospective analysis. These patients were treated at the University Hospital in Essen between 2017 and 2025 within the framework of a

Eligibility

Sex/Gender

All

Age

4 Years to 39 Years

Inclusion criteria

Inclusion criteria: Patients between the ages of 4 and 39 with a histologically confirmed diagnosis of Ewing Sarcoma or osteosarcoma were included in the study. Patients were identified by means of the electronic patients records in the hospital information system. Patients had to receive neoadjuvant first-line chemotherapy according to protocol (EWING 2008/ EWING 2012/ iEuroEwing or EURAMOSS/COSS), undergo surgical removal of the tumour and receive histopathological processing of the tumour cells according to Salzer-Kuntschik at the time of surgery. Furthermore, patients were included only if supervised exercise therapy sessions between diagnosis and surgery were reliably documented.

Exclusion criteria

Exclusion criteria: Exclusion criteria were inoperability of the tumour, which is often associated with radiotherapy, or cases of recurrence therapy.

Design outcomes

Primary

Measure	Time frame
The primary endpoint of this retrospective study is the impact of supervised exercise therapy sessions during neoadjuvant chemotherapy on the proportion of viable tumor cells at the time of surgery in patients with Ewing sarcoma or osteosarcoma. The proportion of viable tumor cells will be dichotomized (<10% vs. =10% viable tumor cells) based on established histopathological criteria and previously published study findings	—

Measure

Time frame

The primary endpoint of this retrospective study is the impact of supervised exercise therapy sessions during neoadjuvant chemotherapy on the proportion of viable tumor cells at the time of surgery in patients with Ewing sarcoma or osteosarcoma. The proportion of viable tumor cells will be dichotomized (<10% vs. =10% viable tumor cells) based on established histopathological criteria and previously published study findings

—

Secondary

Measure	Time frame
The secondary outcomes are to evaluate the effect of supervised exercise therapy during neoadjuvant chemotherapy on changes in tumor volume and to examine the potential influence of age and body mass index (BMI) on tumor activity. Additionally, subgroup analyses will be performed to determine whether disease staging and metastatic status are associated with participation in supervised exercise therapy sessions	—

Measure

Time frame

The secondary outcomes are to evaluate the effect of supervised exercise therapy during neoadjuvant chemotherapy on changes in tumor volume and to examine the potential influence of age and body mass index (BMI) on tumor activity. Additionally, subgroup analyses will be performed to determine whether disease staging and metastatic status are associated with participation in supervised exercise therapy sessions

—

Countries

Germany

Contacts

Public ContactMiriam Götte

Institut für Sport- und Bewegungstherapie am WTZ Essen

Suzan.Botzenhardt@uk-essen.de0049 723 86390

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 29, 2026