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Reference testing of diffusing capacity of the lung for carbon monoxide and single-breath helium dilution body plethysmography in healthy individuals in Mbeya, Tanzania

Reference testing of diffusing capacity of the lung for carbon monoxide and single-breath helium dilution body plethysmography in healthy individuals in Mbeya, Tanzania - DLCO and static lung volume reference study Mbeya

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00040646
Enrollment
100
Registered
2026-06-18
Start date
2026-05-08
Completion date
Unknown
Last updated
2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

R94.2

Interventions

Group 1: Cross sectional observational study in which healthy volunteers take part in lung function measurements at a single time point. Demographic data are collected at the same single study visit.

Sponsors

Klinikum der Universität München, Institut für Infektions- und Tropenmedizin
Lead Sponsor
National Institute for Medical Research, Mbeya Medical Research Center
Collaborator

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Able and willing to provide informed consent - Resident of the study area

Exclusion criteria

Exclusion criteria: - Respiratory symptoms at screening (including but not limited to cough, sore throat, sputum production, sneezing, running nose, wheezing, shortness of breath, general signs potentially indicative of an ongoing airway infection like fever, and other symptoms potentially interfering with lung function testing) - Past or present chronic respiratory disease (e.g., asthma, COPD, cystic fibrosis, post-tuberculosis sequelae, other) - Any contraindication for spirometry (see CRF) - Past or present tuberculosis disease - Any condition that may lead to uncooperative behavior (e.g., psychiatric illness, alcoholism, other) - Past or present smoker - Diseases or anatomic abnormality possibly altering spirometry results (higher degree scoliosis, muscular disease, other) - Previous lung surgery or severe chest trauma (e.g., due to traffic accident) - Known current or past anemia or anemia treatment

Design outcomes

Primary

MeasureTime frame
Lung function including total lung volume and diffusion capacity for carbon monoxide as per single lung function test

Secondary

MeasureTime frame
dependence of lung function on demographic features

Countries

Tanzania

Contacts

Public ContactAndrea Rachow

Klinikum der Universität München, Institut für Infektions- und Tropenmedizin

Rachow@lrz.uni-muenchen.de+49 (0)89 4400-59800

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 29, 2026