Ultrasound imaging of placental vascular anastomoses using Slowflow HD in monochorionic twins with twin-to-twin transfusion syndrome before and during fetoscopic laser ablation.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00040636

Enrollment

Registered

2026-06-15

Start date

2025-04-01

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

O43.0

Interventions

Group 1: This study will be the first to use Slowflow HD to visualize the placental vascular equator in monochorionic twins with TTTS. Slowflow HD is a Doppler method featured in GE Healthcare’s new E

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criteria: • Monochorionic multiple pregnancy with TTTS • Live fetuses at the time of examination • Informed and written consent

Exclusion criteria

Exclusion criteria: Exclusion criteria: • Not fluent in the local language and lack of an interpreter

Design outcomes

Primary

Measure	Time frame
Visualization of placental vascular anastomoses before and during fetoscopic laser ablation using Slowflow HD. (yes/no)	—

Secondary

Measure	Time frame
Objectives of this study: 1) Visualization of placental anastomoses before and during fetoscopic laser ablation using ultrasound (Slowflow HD) 2) Differentiation of all types of placental anastomoses on ultrasound 3) Comparison of anastomoses visualized by ultrasound and those visualized during fetoscopic laser ablation 4) In patients who gave birth at Charité: Comparison of anastomoses visualized by ultrasound and those ablated, with confirmation of closed/open anastomoses during postpartum staining of placental vessels	—

Measure

Time frame

Objectives of this study: 1) Visualization of placental anastomoses before and during fetoscopic laser ablation using ultrasound (Slowflow HD) 2) Differentiation of all types of placental anastomoses on ultrasound 3) Comparison of anastomoses visualized by ultrasound and those visualized during fetoscopic laser ablation 4) In patients who gave birth at Charité: Comparison of anastomoses visualized by ultrasound and those ablated, with confirmation of closed/open anastomoses during postpartum staining of placental vessels

—

Countries

Germany

Contacts

Public ContactChristian Bamberg

Charité Geburtsmedizin

christian.bamberg@charite.de015111654355

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 29, 2026