Oral health and oral diseases: investigation of microbial, immunological and molecular markers in different intraoral tissues and niches
Conditions
Interventions
Group 1: Prospective observational study involving the collection of intraoral biospecimens and clinical data during routine dental care. After written informed consent, saliva, sub- and supragingival
Sponsors
Universitätsklinikum Köln – Zentrum für Zahn-, Mund- und Kieferheilkunde, Poliklinik für Zahnerhaltung und Parodontologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: * Age = 18 years * Indication for dental treatment or dental follow-up care * Willingness to provide written informed consent for study participation and use of biomaterials for research purposes * Availability of biospecimens obtained during routine dental care
Exclusion criteria
Exclusion criteria: * Age < 18 years * Lack of capacity to provide informed consent * Missing written informed consent * Refusal to allow the use of biomaterials for research purposes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identification and characterization of microbial and immunological markers in different intraoral tissues and niches. Primary outcomes include microbial profiles (composition and functional characteristics) and their associations with immunological parameters. Data are collected at the time of routine sample acquisition using microbiological, molecular biological, and immunological analyses of the collected biospecimens. | — |
Secondary
| Measure | Time frame |
|---|---|
| Establishment of standardized workflows for biospecimen collection and processing and identification of molecular profiles (microbiome, metagenome, transcriptome, proteome, and metabolome) in different intraoral tissues, niches, and inflammatory oral diseases. Outcomes are assessed using clinical data and biospecimen analyses collected throughout the study period. | — |
Countries
Germany
Contacts
Public ContactGreta Barbe
Universitätsklinikum Köln – Poliklinik für Zahnerhaltung und Parodontologie
Outcome results
None listed