Basic physiological study / Method development
Conditions
Interventions
Group 1: Up to three hours of MRI scanning time for the development and optimization of MRI protocols for tracking food components and dosage forms, as well as for quantifying parameters in the digest
Sponsors
Universität Greifswald
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age: 18 years or older Gender: Male and female Medical condition suitable for an MRI scan (to be assessed on a case-by-case basis by the study physician) Submission of a written informed consent form
Exclusion criteria
Exclusion criteria: • Disorders or conditions affecting the swallowing process (e.g., severe dysphagia related to food and/or solid oral medications) • Claustrophobia • Liver disease • Implanted or portable electromechanical medical devices such as pacemakers, defibrillators, or infusion pumps • Extensive dark tattoos • Known allergies or intolerances to the components of the liquids • Alcohol or drug addiction • Eating disorders such as anorexia, bulimia • Positive pregnancy test, pregnancy, or current desire to conceive • Individuals known to be unwilling or unable to reliably follow instructions • Individuals unable to understand written and verbal instructions and information regarding the study risks they will face • Less than 14 days after an acute illness • Systemic use of medications, particularly those that affect gastrointestinal function • Concurrent participation in interventional research studies; the interval since previous participation in other studies should not be less than 14 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Development of methods for (real-time) MRI of the mouth, esophagus, and abdomen | — |
Secondary
| Measure | Time frame |
|---|---|
| Tracking of orally ingested liquids/food components and dosage forms in the gastrointestinal tract. Development of measurement protocols for future studies. | — |
Countries
Germany
Contacts
Public ContactWerner Weitschies
Universität Greifswald
Outcome results
None listed