E03
Conditions
Interventions
Group 1: Participants take their usual dose of levothyroxine around 120 minutes before the measurement starts.
Group 2: Participiants dont take their medication before the measurement. The Measurement
Sponsors
University of Hamburg, Institute of Human Movement Science, Department of Sports and Exercise Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: - diagnosed hypothyroidism - levothyroxine monotherapy for at least 6 months - stable levothyroxine dose for at least 3 months
Exclusion criteria
Exclusion criteria: - Current use of other medications known to influence resting energy expenditure - Current use of thyroid medication other than levothyroxine - Clinically relevant sleep disturbances
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Within-participant difference in resting energy expenditure (kcal/day), assessed by indirect calorimetry, between regular morning levothyroxine intake and a single omission on the measurement day. Both measurements are performed in the morning after an overnight fast and a 10-minute resting period, with a maximum interval of 7 days. | — |
Secondary
| Measure | Time frame |
|---|---|
| Within-participant differences in respiratory quotient and substrate oxidation, particularly fat and carbohydrate oxidation (%), assessed by indirect calorimetry, between regular morning levothyroxine intake and a single omission on the measurement day. Both measurements are performed in the morning after an overnight fast and a 10-minute resting period, with a maximum interval of 7 days. | — |
Countries
Germany
Contacts
Public ContactKim-Charline Broscheid
Universität Hamburg
Outcome results
None listed