G40
Conditions
Interventions
Group 1: For each included patient, a resting-state fMRI scan and a resting-state EEG recording
are performed. Resting-state BOLD responses are analyzed in terms of complexity and functional
connectiv
Sponsors
Universitätsmedizin Frankfurt am Main
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Adult patients with MRI-positive findings and suspected FCD Type IIB. - Adult patients with unilateral focal epilepsy for whom the location of the seizure focus and the irritative zone was determined during video-EEG monitoring according to Rosenow & Lüders (2001). - Adult patients with psychogenic non-epileptic seizures without epilepsy, who will serve as the control group. - Voluntary participation following an explanation of the benefits and risks of the study. - Verbal and written consent from the participant to participate in the study and to have data collected.
Exclusion criteria
Exclusion criteria: - Common exclusion criteria for undergoing an fMRI scan, such as o Pacemaker o Vagus nerve stimulator o Neurostimulator or drug infusion pump o Metal objects near the head (e.g., splinters, surgical clips or staples, cochlear implants; also: metal splinters in the body, e.g., due to work in the metalworking industry) o Recent skull fractures o Alcohol consumption within the last 12 hours prior to the examination - Alcoholism, medication abuse, and drug abuse - Confirmed or suspected pregnancy based on medical history - Participants who lack legal capacity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The implementation of dynamic complexity analysis is intended to test the following hypotheses: a) Across all study participants: (1) All participants exhibit recurring drops in neural complexity. b) Comparison of patients and controls with non-epileptic seizures who do not have epilepsy: (1) Frequency of complexity drops: Both patients in Group I and Group II show a higher number of complexity drops compared to individuals in Group III. (2) Duration of complexity drops: The duration of individual complexity drops in both patient groups differs from that of controls with non-epileptic seizures without epilepsy. (3) Amplitude of complexity drops: The decrease in neural complexity during the drops is more pronounced in both patient groups than in controls with non-epileptic seizures without epilepsy. (4) Spatial distribution: Complexity drops occur more frequently in both patient groups within epileptogenic networks and exhibit more focal spatial patterns than in individuals with non-epileptic seizures. | — |
Secondary
| Measure | Time frame |
|---|---|
| Exploratory analysis between Groups I and II: (1) Differences in frequency and duration: MRI-negative patients may exhibit a different frequency or duration of complexity drops than MRI-positive patients, which could indicate subtle differences in network pathophysiology. (2) Spatial differences: The distribution of complexity drops across the brain varies between MRI-positive and MRI-negative FCD, with MRI-negative patients potentially exhibiting patterns that are less clearly localizable. | — |
Countries
Germany
Contacts
Public ContactAntje Peters
Universitätsmedizin Frankfurt am Main
Outcome results
None listed