Eye Tracking for the Assessment of Learning Performance in Children and Adolescents with Seizures and a Healthy Control Group

Eye Tracking for the Assessment of Learning Performance in Children and Adolescents with Seizures and a Healthy Control Group - ELLA

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00040492

Enrollment

110

Registered

2026-06-25

Start date

2025-11-25

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy and first unprovoked seizure

Interventions

Group 1: After informed consent and written assent/consent have been obtained, participants will undergo a single administration of the neuropsychological screening test EpiTrack Junior while wearing

Eligibility

Sex/Gender

All

Age

6 Years to 17 Years

Inclusion criteria

Inclusion criteria: - Children and adolescents with epilepsy or a first unprovoked epileptic seizure - Healthy children and adolescents (control group) - Written informed consent from legal guardians as well as assent/consent from participants according to age and capacity to understand

Exclusion criteria

Exclusion criteria: - Insufficient ability to cooperate or inability to complete the assessment as judged by the investigators - Insufficient German language proficiency - Known tonic or atonic drop seizures (clinical cohort only; safety aspect related to the eye-tracking device) - Neurological disorders or chronic diseases involving the central nervous system (healthy control group only)

Design outcomes

Primary

Measure	Time frame
Primary endpoint: Objective assessment of cognitive changes, particularly executive functions, using eye-tracking parameters and derived measures during the EpiTrack Junior assessment. Recorded parameters include eye movement patterns (e.g., fixation duration, saccade frequency), pupil diameter, gaze shifts, reaction times to visual stimuli/tasks, and problem-solving behavior (number and type of errors/solutions). Timepoint(s) of assessment: For participants with epilepsy and healthy controls, assessments are performed once at study inclusion. For the cohort with a first unprovoked epileptic seizure, assessments are performed at baseline and repeated after 8–12 weeks. Method of data collection: Data are collected during administration of the EpiTrack Junior neuropsychological screening test in combination with an eye-tracking device (Pupil Labs Neo glasses). Clinical and demographic data are additionally obtained from medical records and participant/parent interviews.	—

Measure

Time frame

Primary endpoint: Objective assessment of cognitive changes, particularly executive functions, using eye-tracking parameters and derived measures during the EpiTrack Junior assessment. Recorded parameters include eye movement patterns (e.g., fixation duration, saccade frequency), pupil diameter, gaze shifts, reaction times to visual stimuli/tasks, and problem-solving behavior (number and type of errors/solutions). Timepoint(s) of assessment: For participants with epilepsy and healthy controls, assessments are performed once at study inclusion. For the cohort with a first unprovoked epileptic seizure, assessments are performed at baseline and repeated after 8–12 weeks. Method of data collection: Data are collected during administration of the EpiTrack Junior neuropsychological screening test in combination with an eye-tracking device (Pupil Labs Neo glasses). Clinical and demographic data are additionally obtained from medical records and participant/parent interviews.

—

Secondary

Measure	Time frame
Secondary endpoint: Assessment of potential associations between eye-tracking parameters and the results of selected subtests of the EpiTrack Junior. In addition, correlation coefficients, prediction accuracy, precision, sensitivity, and potential classifications will be analyzed. Timepoint(s) of assessment: For children and adolescents with epilepsy and healthy controls, assessments are performed once at study inclusion. For the cohort with a first unprovoked epileptic seizure, assessments are performed at baseline and repeated after 8–12 weeks. Method of data collection: Data are collected during administration of the EpiTrack Junior neuropsychological screening test in combination with an eye-tracking device (Pupil Labs Neo). Secondary endpoints are determined through statistical analyses of the recorded eye-tracking data and the corresponding EpiTrack Junior subtest results.	—

Measure

Time frame

Secondary endpoint: Assessment of potential associations between eye-tracking parameters and the results of selected subtests of the EpiTrack Junior. In addition, correlation coefficients, prediction accuracy, precision, sensitivity, and potential classifications will be analyzed. Timepoint(s) of assessment: For children and adolescents with epilepsy and healthy controls, assessments are performed once at study inclusion. For the cohort with a first unprovoked epileptic seizure, assessments are performed at baseline and repeated after 8–12 weeks. Method of data collection: Data are collected during administration of the EpiTrack Junior neuropsychological screening test in combination with an eye-tracking device (Pupil Labs Neo). Secondary endpoints are determined through statistical analyses of the recorded eye-tracking data and the corresponding EpiTrack Junior subtest results.

—

Countries

Germany

Contacts

Public ContactAlexandra Klotz

Universitätsklinikum Bonn – Zentrum für Kinder- und Jugendmedizin, Abteilung Neuropädiatrie/SPZ

epilepsie-kinderneurologie@ukbonn.de+49 228 287 37575

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 10, 2026