J18.9
Conditions
Interventions
Group 1: Bronchoalveolar lavage fluid (BALF) and blood samples are collected from 150 patients with suspected or confirmed pneumonia requiring mechanical ventilation. These samples are used for standa
Sponsors
Klinik für Anästhesiologie und operative Intensivmedizin, Uniklinikum Bonn
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients requiring mechanical ventilation with suspected or proven pneumonia
Exclusion criteria
Exclusion criteria: 1. Pregnancy 2. Age < 18 years old 3. Missing signed consent from the subject/patient or their legal representative to participate in the study and/or to the privacy policy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The aim of this single center clinical observative trial is to evaluate the diagnostic performance (sensitivity, specificity, positive predictive value, negative predictive value, interrater-reliability using kappa statistics) of NGS-based diagnostics in comparison to culture and molecular based pathogen detection evaluating patients with suspected or proven pneumonia requiring mechanical ventilation. In addition, the present study will serve to retrospectively assess the clinical value of NGS-based diagnostics. For this purpose, an independent panel of experts will answer the question in each individual patient to what extent additional knowledge of the NGS results would have led to a change in the anti-infective therapy strategy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Furthermore, it should be determined in which compartment (blood or BALF) NGS-based diagnostics demonstrate higher sensitivity and specificity for pathogen detection | — |
Countries
Germany
Contacts
Public ContactChristian Bode
Klinik für Anästhesiologie und operative IntensivmedizinUniklinikum Bonn
Outcome results
None listed