Evaluation and Validation of Established Prognostic Markers in Patients with HNSCC-CUP (Head and Neck Squamous Cell Carcinoma of Unknown Primary)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00040483

Enrollment

Registered

2026-06-01

Start date

2026-10-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C80.0

Interventions

Group 1: Retrospective analysis of all patients for whom material from a squamous cell head and neck carcinoma with an unknown primary site is available since 2012.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with squamous cell carcinoma of the head and neck with unknown primary

Exclusion criteria

Exclusion criteria: Healthy or No Squamous Cell Carcinoma of the Head and Neck with Unknown Primary

Design outcomes

Primary

Measure	Time frame
Do discordances in established markers for therapeutic response and clinical course have an impact in HNSCC-CUP, and can they serve as predictors for therapeutic response and clinical course in HNSCC-CUP?	—

Secondary

Measure	Time frame
Can extracapsular tumor spread (ECS) be utilized as an additional or supplementary predictor?	—

Countries

Germany

Contacts

Public ContactKatharina Klinger

Klinik für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie, Universitätsklinikum Essen

katharina.klinger@uk-essen.de0201 723 0

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 10, 2026