studying healthy volunteers
Conditions
Interventions
Group 1: Intradermal Injection (100µl, randomisiert) into volar forearm skin of NaCl (0.9%), Sulproston 0,043 fg (PGE2-Analogon, Nalador-500®, Alprostadil 0,017 fg (PGE1 Analogon, Caverject® 10 µg), V
Sponsors
Experimentelle Schmerzforschung
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Knowledge of german or english langage
Exclusion criteria
Exclusion criteria: Not able to communicate in german or english language, chronic pain, neuropathy, diabetes, psychic deseases, skin desease with acute symptoms and impairmentof the skin barrier at the forearm, regular itake of medications that can influence pain perception, regular consumption of other compounds that may influnce pain perception (for instance drugs or alcohol abuse), pregnant or breast-feeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intensity of sensation during electrical and constant heat stimulation before and 5 minutes after intradermal injection. | — |
Secondary
| Measure | Time frame |
|---|---|
| Intensity of local vasodilation after electrical stimulation of the skin before and 5 minutes after intradermal injection. | — |
Countries
Germany
Contacts
Public ContactRoman Rukwied
Experimentelle Schmerzforschung
Outcome results
None listed