F50.0
Conditions
Interventions
Group 1: Study arm 1 includes adolescent patients with anorexia nervosa in an outpatient setting. Following a baseline assessment, two follow-up visits are scheduled at 2 and 4 months. Clinical, anthr
Sponsors
LVR-Universitätsklinikum Essen, Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, Institut der Universität Duisburg-Essen
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: Inclusion and Exclusion Criteria Participation in this study is not permitted if the participant is concurrently enrolled in a study that could influence energy metabolism, physical activity patterns, or treatment outcomes (interventional studies). Participation in other observational studies is permitted. Participation in parallel studies will be discussed with potential patients/participants during the informed consent discussion. • Inclusion criteria for patients: o Female and male adolescents with AN of the restrictive, binge-purge, or atypical type (DSM-5) o Age 12–18 years o Informed consent following study briefing from patients and their legal guardians Control group inclusion: o Normal weight according to BMI percentiles (20th–80th percentile) o Healthy (no known medical conditions) o Age 12.00–18.00 years o Negative EAT-8 questionnaire (= 0 points) o Submission of the legal guardian’s informed consent form o Socioeconomic status comparable to the AN group (via matching) Inclusion of the risk group: o Normal weight according to BMI percentiles (20th–80th percentiles) o Healthy (no known medical conditions) o Age 12.00–18.00 years o EAT-8 questionnaire positive (> 0 points) o Written consent from legal guardians o Age and socioeconomic status comparable to the AN group
Exclusion criteria
Exclusion criteria: Patient exclusion criteria: o Any direct limitation of physical activity, such as partial paralysis or acute fractures o Acute psychosis or mania as a comorbid condition o (Cerebral) organic psychosis o Conditions affecting energy metabolism (e.g., type 1 or type 2 diabetes mellitus, hyperthyroidism or hypothyroidism, Cushing’s syndrome, obesity, congenital metabolic disorders). Exclusion criteria for the control group: o Current or past eating disorder o Participation in competitive sports o Presence of a condition affecting energy metabolism or physical activity o Conditions affecting energy metabolism (e.g., type 1 or type 2 diabetes mellitus, hyperthyroidism or hypothyroidism, Cushing’s syndrome, obesity, congenital metabolic disorders) Exclusion criteria for the risk group: o Current or past manifest eating disorder o Overweight or underweight o Participation in competitive sports o Presence of a condition affecting energy metabolism or physical activity o Conditions affecting energy metabolism (e.g., type 1 or type 2 diabetes mellitus, hyperthyroidism or hypothyroidism, Cushing’s syndrome, obesity, congenital metabolic disorders)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in physical activity | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in body weight, energy and nutrient intake, AN psychopathology, leptin levels, differences in the gut microbiome. This project aims to elucidate the biological role of dietary changes and physical activity in the development and maintenance of AN. A better understanding of the interaction between macronutrient intake and physical activity, as well as the identification of suitable biomarkers, may lead to the identification of risk groups and factors for eating disorders. Additional secondary endpoints include: o Changes in intestinal permeability (e.g., zonulin), o A reduction in gastrointestinal symptoms (gastrointestinal questionnaire), and the likelihood of relapse. o The identification of associations between microbiome profiles and the severity of AN o The investigation of the urinary steroid metabolome as a potential prognostic biomarker for depression in AN. | — |
Countries
Germany
Contacts
Public ContactJochen Seitz
LVR-Universitätsklinikum Essen, Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, Institut der Universität Duisburg-Essen
Outcome results
None listed