The Significance of the Irritative Zone in Presurgical Epilepsy Diagnostics

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00040415

Enrollment

620

Registered

2026-06-08

Start date

2025-09-20

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

drug-resistant focal epilepsies G40.2

Interventions

Group 1: Retrospective analysis of data from patients who were admitted to the video-EEG monitoring unit of the Epilepsiezentrum Hessen over a 10-year period (2015–2024). The analysis will be conducte

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Data analysis of patients who received treatment between 2015 and 2024

Exclusion criteria

Exclusion criteria: Patient age < 18 years

Design outcomes

Primary

Measure	Time frame
The aim of this study is to determine the sensitivity of video-EEG monitoring (VEM) within the presurgical evaluation of epilepsy with regard to the detection of interictal epileptiform discharges (IEDs) in patients with focal epilepsy. Particular emphasis will be placed on the interplay between seizure semiology, EEG findings, and MRI findings, as well as their influence on the indication for epilepsy surgery and the corresponding postoperative outcome. One component of this investigation is the comparison of patients with and without evidence of IEDs during VEM. Demographic and clinical characteristics, including age, duration of epilepsy, seizure type, neuroimaging findings (particularly MRI findings), and seizure frequency, will be systematically compared between these groups.	—

Measure

Time frame

The aim of this study is to determine the sensitivity of video-EEG monitoring (VEM) within the presurgical evaluation of epilepsy with regard to the detection of interictal epileptiform discharges (IEDs) in patients with focal epilepsy. Particular emphasis will be placed on the interplay between seizure semiology, EEG findings, and MRI findings, as well as their influence on the indication for epilepsy surgery and the corresponding postoperative outcome. One component of this investigation is the comparison of patients with and without evidence of IEDs during VEM. Demographic and clinical characteristics, including age, duration of epilepsy, seizure type, neuroimaging findings (particularly MRI findings), and seizure frequency, will be systematically compared between these groups.

—

Secondary

Measure	Time frame
Detection of interictal epileptiform discharges (IEDs) Localization of the irritative zone Association between IED detection and postoperative seizure outcome Impact of irritative zone localization Impact of MRI findings	—

Countries

Germany

Contacts

Public ContactLeona Möller

Universitätsklinikum Marburg

leona.moeller@med.uni-marburg.de+49 (0)6421 58 65435

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 29, 2026