F50.0
Conditions
Interventions
Group 1: The study examines how the disease, the gut microbiome, and various biological markers evolve over time in adolescents hospitalized with anorexia nervosa. To this end, questionnaires, blood,
these include questionnaires, blood, stool, and urine samples, as well as MRI scans for some of the participants. Control participants will be recruited through the patients’ friends and acquaintances
Sponsors
LVR-Universitätsklinikum Essen, Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, Institut der Universität Duisburg-Essen
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: Patients: • female and male adolescents with anorexia nervosa (restrictive or binge-purge type) and atypical anorexia, • aged 12 to 18 years, • written informed consent from the patient and their legal guardian. Control subjects: • normal weight within the 20th to 80th BMI percentile, • no current psychiatric comorbidity, • no current or previous eating disorder, • aged 12 to 18 years, • written informed consent.
Exclusion criteria
Exclusion criteria: The following are excluded, amongst others: • organic brain disorders, • psychosis, • bipolar disorder, • substance use disorders, • an IQ < 80, • insufficient knowledge of German, • relevant organic diseases affecting the gastrointestinal tract or metabolism, • pregnancy, • use of antibiotics in the last 6 weeks, • contraindications to MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in the median BMI (delta % mBMI) over 12 months following hospital admission. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in body weight, energy and nutrient intake, AN psychopathology (EDI-2, EDE-Q), bacterial diversity and activity, inflammatory parameters, and depressive symptoms (PHQ-9, BDI-II). Further secondary endpoints: Changes in microbiome composition, intestinal permeability (zonulin), gastrointestinal symptoms, relapse probability, microRNAs, circRNAs, the urinary steroid metabolome, and the association of leptin with physical and psychological signs of starvation. | — |
Countries
Germany
Contacts
Public ContactJochen Seitz
LVR-Universitätsklinikum Essen, Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, Institut der Universität Duisburg-Essen
Outcome results
None listed