The Tinnitus Network: Treatment-related changes in resting-state functional connectivity

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00040335

Enrollment

Registered

2026-06-11

Start date

2024-02-14

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

H93.1

Interventions

Group 1: Interdisciplinary tinnitus treatment: specialized interdisciplinary day-clinic treatment, conducted over five consecutive days (Jena Interdisciplinary Treatment for Tinnitus, JITT). Following

Eligibility

Sex/Gender

All

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Chronic subjective tinnitus (minimum duration 3 months) with tinnitus-related distress of at least grade 2 according to the Tinnitus Questionnaire (TQ, Goebel & Hiller) Signed informed consent

Exclusion criteria

Exclusion criteria: Severe hearing loss (> 60 dB) Severe neurological disorders or acute psychiatric disorders preventing participation in group treatment Otological diseases or other rehabilitation therapies that might interfere with study participation Metal implants precluding MEG measurement Use of psychotropic medication

Design outcomes

Primary

Measure	Time frame
Changes in resting-state functional connectivity, measured by magnetoencephalography (MEG), at T1 (first day of treatment) and T2 (approximately 3.5 weeks later, following completion of the five-day treatment and the subsequent hearing aid training phase).	—

Secondary

Measure	Time frame
Questionnaire assessments were conducted at four time points (Q1, Q2, Q3): Q1/T1 (first day of treatment), T2 (approximately 3.5 weeks after T1), Q2 (3 months after Q1), and Q3 (3 months after Q2). T1/Q1 and T2 (MEG assessment time points): Tinnitus-related distress, Tinnitus Questionnaire (TQ, Goebel & Hiller) (primary measure) State anxiety, State-Trait Anxiety Inventory, State Scale (STAI-S) Current affective state, Positive and Negative Affect Schedule (PANAS) T1/Q1, Q2 and Q3 (questionnaire time points, each 3 months apart): Tinnitus-related distress, Tinnitus Questionnaire (TQ, Goebel & Hiller) Self-efficacy, optimism and pessimism (SWOP) Perceived stress, Perceived Stress Questionnaire (PSQ-20) Depressive symptoms, Center for Epidemiologic Studies Depression Scale (CES-D) Current mood state, Mood Adjective Checklist (BSF) Physical complaints, Berlin Complaint Inventory (BI) Pain sensitivity, Pain Sensitivity Questionnaire (SES – Schmerzempfindungsskala) ICD-10-based symptom severity, ICD-10 Symptom Rating (ISR) T1/Q1 and Q3 (supplementary tinnitus outcome measures): Tinnitus Handicap Questionnaire (THQ) Tinnitus Handicap Inventory (THI) Tinnitus Functional Index, Version 2 (TFI-2) Baseline (T1/Q1 only): Demographic and socioeconomic information (SOZ-K) Depressive symptoms, Beck Depression Inventory (BDI) Trait anxiety, State-Trait Anxiety Inventory, Trait Scale (STAI-T) Intolerance of uncertainty, Intolerance of Uncertainty Scale (UI-18) Patient Health Questionnaire (PHQ-D) (All questionnaires were administered in their German versions.)	—

Measure

Time frame

Questionnaire assessments were conducted at four time points (Q1, Q2, Q3): Q1/T1 (first day of treatment), T2 (approximately 3.5 weeks after T1), Q2 (3 months after Q1), and Q3 (3 months after Q2). T1/Q1 and T2 (MEG assessment time points): Tinnitus-related distress, Tinnitus Questionnaire (TQ, Goebel & Hiller) (primary measure) State anxiety, State-Trait Anxiety Inventory, State Scale (STAI-S) Current affective state, Positive and Negative Affect Schedule (PANAS) T1/Q1, Q2 and Q3 (questionnaire time points, each 3 months apart): Tinnitus-related distress, Tinnitus Questionnaire (TQ, Goebel & Hiller) Self-efficacy, optimism and pessimism (SWOP) Perceived stress, Perceived Stress Questionnaire (PSQ-20) Depressive symptoms, Center for Epidemiologic Studies Depression Scale (CES-D) Current mood state, Mood Adjective Checklist (BSF) Physical complaints, Berlin Complaint Inventory (BI) Pain sensitivity, Pain Sensitivity Questionnaire (SES – Schmerzempfindungsskala) ICD-10-based symptom severity, ICD-10 Symptom Rating (ISR) T1/Q1 and Q3 (supplementary tinnitus outcome measures): Tinnitus Handicap Questionnaire (THQ) Tinnitus Handicap Inventory (THI) Tinnitus Functional Index, Version 2 (TFI-2) Baseline (T1/Q1 only): Demographic and socioeconomic information (SOZ-K) Depressive symptoms, Beck Depression Inventory (BDI) Trait anxiety, State-Trait Anxiety Inventory, Trait Scale (STAI-T) Intolerance of uncertainty, Intolerance of Uncertainty Scale (UI-18) Patient Health Questionnaire (PHQ-D) (All questionnaires were administered in their German versions.)

—

Countries

Germany

Contacts

Public ContactChristian Dobel

Universitätsklinikum Jena

Christian.Dobel@med.uni-jena.de+4936419329374

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 29, 2026