Corticobasal Syndrome (CBS)
Conditions
Interventions
Group 1: As part of this longitudinal intervention study, the first baseline assessment (T0) is conducted after enrollment, followed by a 4-week waiting period to evaluate spontaneous improvements in
UPDRS Part 3, which measures motor impairment associated with Parkinson’s symptoms
and assessments of cognitive impairment using the CERAD-Plus test battery, the severity of dementia using the CRD, and affective symptoms using the GDS. In addition, MRI measurements of cortical GABA
Sponsors
Klinik für Psychiatrie, Psychotherapie und Psychosomatik der Universität Augsburg
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: Participating patients must exhibit the clinical symptoms required for the diagnosis of possible corticobasal syndrome (CBS), which is defined in this study as a combination of at least one extrapyramidal motor symptom and apraxia as a cortical symptom.
Exclusion criteria
Exclusion criteria: Exclusion criteria include severe or unstable physical, neurological or medical conditions, acute suicidal tendencies or existing suicidal thoughts, known epilepsy, the presence of metallic medical implants in the brain and/or skull (e.g. deep brain stimulators, cochlear implant, arterial coils or arterial clips), blindness, deafness or a primary diagnosis of substance dependence (with the exception of nicotine use).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in apraxia as assessed by the clinical DATE score This is assessed at the T2 assessment point, 8 weeks after the baseline assessment The data are collected through clinical assessment using the DATE score | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in cortical GABA levels in the parietal cortex, as determined by MR spectroscopy; improvement in other clinical parameters such as motor impairment, as assessed by UPDRS Part III; cognitive parameters, as assessed by the CERAD test battery; stage of dementia, as assessed by the CDR; and affective symptoms, as assessed by the GDS | — |
Countries
Germany
Contacts
Public ContactJan Häckert
Klinik für Psychiatrie, Psychotherapie und Psychosomatik der Universität Augsburg
Outcome results
None listed