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Multiclot in Acute and Perioperative Medicine: Analysis of Routinely Measured Viscoelastic Coagulation Parameters in Clinical Care

Multiclot in Acute and Perioperative Medicine: Analysis of Routinely Measured Viscoelastic Coagulation Parameters in Clinical Care

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00040239
Enrollment
60
Registered
2026-05-07
Start date
2026-08-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative haemostatic disorders and coagulopathies in cardiac surgery patients, including functional fibrinogen disturbances and residual heparin effects following protamine administration in the context of cardiopulmonary bypass.

Interventions

Group 1: Observation of cardiac surgery patients under routine care with perioperative viscoelastic coagulation monitoring (Multiclot®) and parallel standard laboratory coagulation testing. No study-r

Sponsors

Universitätsklinikum Bonn, Klinik für Anästhesie und Operative Intensivmedizin
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Performing cardiac surgery, conducting viscoelastic and coagulation testing as part of routine clinical practice

Exclusion criteria

Exclusion criteria: No Multiclot testing performed, No coagulation testing performed

Design outcomes

Primary

MeasureTime frame
Correlation coefficient (Pearson or Spearman, depending on the assumption of distribution) between the measurements from the Multiclot FIB-test and the laboratory-based fibrinogen assay according to Clauss. Bland-Altman analysis to determine the mean deviation (bias) and the limits of agreement (LoA = bias ± 1.96 SD) between the two measurement methods

Secondary

MeasureTime frame
Changes in HI-test parameters before vs. after protamine administration. Descriptive analysis of additional diagnostic information using Multiclot.

Countries

Germany

Contacts

Public ContactFlorian Piekarski

Universitätsklinikum Bonn, Klinik für Anästhesiologie und Operative Intensivmedizin

florian.piekarski@ukbonn.de+4922828714114

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 10, 2026