Prevalence and Subtypes of Human Herpesvirus 8 in People Living with HIV as Predictors of HHV-8-Associated Lymphoproliferative Disorders, Malignancies, and Inflammatory Manifestations: A Combined Seroprevalence and Multicenter Cohort Study to Identify Diagnostic Gaps

Prevalence and Subtypes of Human Herpesvirus 8 in People Living with HIV as Predictors of HHV-8-Associated Lymphoproliferative Disorders, Malignancies, and Inflammatory Manifestations: A Combined Seroprevalence and Multicenter Cohort Study to Identify Diagnostic Gaps - HHV-8: Epidemiology, Disease Burden, and Laboratory Diagnostics

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00040235

Enrollment

5100

Registered

2026-05-06

Start date

2024-03-21

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HHV-8-associated disorders

Interventions

Group 1: For the seroprevalence part of the study, blood samples from 5,000 people living with HIV will be evaluated. Group 2: In the multicenter component of the study, associations between HHV-8 sub

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: For the multicentre component: Written informed consent from patients.

Exclusion criteria

Exclusion criteria: For the multicentre component: Missing informed consent.

Design outcomes

Primary

Measure	Time frame
Seroprevalence component: Prevalence of antibodies against HHV-8 in a representative cohort of people living with HIV. Multicentre component: Distribution of HHV-8 subtypes across different disease entities and clinical courses in people living with HIV who have an HHV-8-associated disease.	—

Secondary

Measure	Time frame
Seroprevalence component: Prevalence and titers of latent and lytic HHV-8 antibodies Prevalence and level of HHV-8 viremia Distribution of HHV-8 subtypes Associations with age groups, sex, HIV viral load, immune status, and inflammatory markers Multicenter component: Identification of HHV-8 risk subtypes associated with aggressive disease courses	—

Countries

Germany

Contacts

Public ContactPascal Migaud

Klinik für Infektiologie, St. Joseph Krankenhaus Berlin-Tempelhof

pascal.migaud@sjk.de+49 30 7882 5508

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026