L30.9
Conditions
Interventions
Group 1: Chronic hand eczema (CHE) is a highly prevalent inflammatory skin disease and is among the most common work-related dermatoses. Up to two-thirds of affected individuals develop a chronic cour
Sponsors
Klinik für Dermatologie und Allergologie - Hautklinik
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: For patients with CHE: Adults (= 18 years) with a confirmed diagnosis of chronic hand eczema (CHE) are eligible to participate. The condition may be of irritant, allergic, or atopic origin and must present clinically with visible skin changes. Inclusion requires willingness to participate in the study and written informed consent for the planned sample collections (skin washing, skin swabs, and nasal swabs). For healthy control subjects: Adults (= 18 years) without any acute or chronic skin diseases are eligible for inclusion. They must not have received systemic or topical treatment with immunosuppressive agents or antibiotics within the past four weeks. As with the patient group, willingness to participate and written informed consent for the sample collections are required.
Exclusion criteria
Exclusion criteria: Persons will be excluded from participating in the study if one or more of the following criteria apply: 1. Individuals under the age of 18 will be excluded. 2. Pregnant and breastfeeding individuals will be excluded, as hormonal changes can affect the skin barrier and immune response. 3. Individuals with acute or chronic skin diseases (applies to healthy control subjects), as these conditions would limit comparability with patients with CHE. 4. Individuals who are unable to provide informed consent, for example due to cognitive impairments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint of the study is the analysis of the protein profile of the skin surface, which is assessed using the performed skin washings. The aim is to identify potentially disease-relevant proteins and to determine differences between individuals with and without CHE. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include the microbiological analysis of skin and nasal swabs to assess microbial colonization. In addition, the gene expression of virulence factors of selected microbial species (S. aureus and/or S. epidermidis) is examined to obtain indications of potentially pathogenic activities. | — |
Countries
Germany
Contacts
Public ContactMarc Burian
Klinik für Dermatologie und Allergologie - Hautklinik
Outcome results
None listed