Spinal Muscular Atrophy (SMA), Duchenne Muscular Dystrophy G12 G71.00
Conditions
Interventions
Group 1: Observational study:
Patients with spinal muscular atrophy (SMA) or Duchenne muscular dystrophy who are scheduled for long-segment dorsal spinal fusion surgery will undergo RT-MRI examinati
Sponsors
Universitätsmedizin Göttingen
Eligibility
Sex/Gender
All
Age
10 Years to 18 Years
Inclusion criteria
Inclusion criteria: Patients between the ages of 10 and 18 with SMA or Duchenne muscular dystrophy who are scheduled for spinal surgery at UMG, who routinely present at our clinic, and whose parents consent to their child’s inclusion in the study. As comparison controls, healthy subjects of the same age and gender as the patients, whose parents consent to their child’s inclusion in the study.
Exclusion criteria
Exclusion criteria: Children with a pacemaker Children with a magnetic implant (e.g., the MAGEC spinal implant) Children with intraocular or intraspinal metal fragments Children with claustrophobia Children with severe swallowing difficulties and a risk of aspiration Children being treated at UMG for another medical condition. Wearing braces is not a contraindication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Swallowing function, potential reflux, and respiratory mechanics, as assessed by MRI, were evaluated before surgery, 3–6 months afterward, and 12 months afterward (or at a single time point for healthy participants). | — |
Secondary
| Measure | Time frame |
|---|---|
| Abnormalities in lung function and in phoniatric and pediatric audiology, as determined by lung function tests and phoniatric and pediatric audiological evaluations, prior to surgery, 3–6 months afterward, and 12 months afterward (or at a single time point for healthy participants). | — |
Countries
Germany
Contacts
Public ContactAnna-Kathrin Hell
Universitätsmedizin Göttingen
Outcome results
None listed