Characterization of Right Ventricular Function in Cardiogenic Shock with Extracorporeal Membrane Oxygenation

Characterization of Right Ventricular Function in Cardiogenic Shock with Extracorporeal Membrane Oxygenation - CHARGE-ECLS

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00040025

Enrollment

Registered

2026-05-11

Start date

2026-04-01

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

R57.0

Interventions

Group 1: The aim of this study is to improve the understanding of the hemodynamic effects of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) on the right ventricle. For this purpose, a one

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Cardiogenic shock with a clinical indication for VA-ECMO therapy Age > 18 years

Exclusion criteria

Exclusion criteria: Insufficient hemodynamic stability despite established VA-ECMO therapy to safely perform study procedures Lack of the possibility to obtain safe venous vascular access Patients with an implanted pacemaker or transvenous implantable cardioverter-defibrillator (ICD) Patients younger than 18 years of age Presence of pregnancy and other particularly vulnerable populations Conditions that make it impossible to obtain informed consent from a legal representative for study participation

Design outcomes

Primary

Measure	Time frame
Change in right ventricular myocardial oxygen consumption when comparing the highest versus lowest rotational speed range of VA-ECMO.	—

Secondary

Measure	Time frame
Change in external ventricular work Change in internal ventricular work Change in pulmonary artery (PA) pressures Change in pulmonary capillary wedge pressure (PCWP) Change in PCWP in relation to external ventricular work RV volume at an RV end-diastolic pressure (RV-EDP) of 10 mmHg Change in RV-EDP RV end-diastolic pressure–volume relationship (RV-EDPVR) Change in RV end-diastolic volume (RV-EDV) RV end-systolic pressure–volume relationship (RV-ESPVR) RV volume at an RV end-systolic pressure (RV-ESP) of 40 mmHg Change in right ventricular afterload (Ea) Change in stroke volume Change in dP/dtmin Change in dP/dtmax Change in heart rate Mortality at 2-year follow-up	—

Measure

Time frame

Change in external ventricular work Change in internal ventricular work Change in pulmonary artery (PA) pressures Change in pulmonary capillary wedge pressure (PCWP) Change in PCWP in relation to external ventricular work RV volume at an RV end-diastolic pressure (RV-EDP) of 10 mmHg Change in RV-EDP RV end-diastolic pressure–volume relationship (RV-EDPVR) Change in RV end-diastolic volume (RV-EDV) RV end-systolic pressure–volume relationship (RV-ESPVR) RV volume at an RV end-systolic pressure (RV-ESP) of 40 mmHg Change in right ventricular afterload (Ea) Change in stroke volume Change in dP/dtmin Change in dP/dtmax Change in heart rate Mortality at 2-year follow-up

—

Countries

Germany

Contacts

Public ContactSebastian Rosch

Johannes-Gutenberg-Universität Mainz – Universitätsmedizin; Zentrum für Kardiologie

roschseb@uni-mainz.de+4915161463112

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026