P07.3
Conditions
Interventions
Group 1: N=60 neonates, including n=50 preterm-born (gestational age =36+6 WoG, at least n=5 per week of gestation from 28+0 WoG
cross-sectional).
Participants will undergo a single assessment at a corrected age of 40 weeks of gestation. Parental history and medical records will be reviewed for maternal conditions, causes of pr
cross-sectional).
Participants will undergo a single assessment. Parental history and medical records will be reviewed for maternal conditions, causes of prematurity, and postnatal clinical course. Th
Sponsors
Klinik für Kardiologie und Angiologie
Eligibility
Sex/Gender
All
Age
No minimum to 17 Years
Inclusion criteria
Inclusion criteria: Neonates: Informed consent from at least one parent / legal guardian. Adolescents: Age-appropriate information and consent from the child, as well as informed consent from at least one parent/legal guardian.
Exclusion criteria
Exclusion criteria: Neonates: Relevant anatomical malformations (especially cerebral, cardiac, and musculoskeletal); pulmonary hypertension; oxygen therapy; catecholamine-dependent circulatory depression; acute neurological disease (Grade IV intracranial hemorrhage, epilepsy); status post (S/P) severe necrotizing enterocolitis with intestinal resection. Adolescents: Status post oncological disease involving chemotherapy or radiotherapy; symptomatic congenital heart defect or one currently requiring treatment; cerebral palsy; epilepsy; chronic eye disease (glaucoma); disease-related limitation of maximal physical exertion (e.g., pulmonary hypertension, acute injuries, motor disorders, or relevant mobility restrictions); inability to follow specific instructions (e.g., documented severe cognitive impairment, psychiatric disorder); acute mental/psychiatric illness requiring pharmacological treatment (e.g., schizophrenia, depression).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pre-post changes in the clinical and molecular vascular profile (composite score) following high-intensity aerobic exercise. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Association of gestational age with the clinical and molecular vascular profile (composite score) in neonates and adolescents. - Comparison of extracellular vesicles in preterm-born versus term-born neonates. - Comparison of vascular inflammatory profile (cytokines) in preterm-born versus term-born neonates. - Comparison of epigenetic age (NeoAge Clock) in preterm-born versus term-born neonates. - Comparison of microbiomic profile in in preterm-born versus term-born neonates. - Comparison of vascular inflammatory profile (cytokines) in preterm-born versus term-born adolescents. - Comparison of epigenetic age (NeoAge Clock) in preterm-born versus term-born adolescents. - Comparison of the microbiomic profile in in preterm-born versus term-born adolescents. - Comparison of the proteomic profile in in preterm-born versus term-born adolescents. - Moderation of the association of FMD with gestational age by a composite lifestyle score, VO2peak and a cardiovascular risk score (BMI, blood pressure, HbA1c, lipid profile, triglycerides) in adolescents. - Moderation of the association of baPWV with gestational age by a composite lifestyle score, VO2peak and a cardiovascular risk score (BMI, blood pressure, HbA1c, lipid profile, triglycerides) in adolescents. - Moderation of the association of SVA (AVR, arteriolar diameter, venular diameter) with gestational age by a composite lifestyle score, VO2peak and a cardiovascular risk score (BMI, blood pressure, HbA1c, lipid profile, triglycerides) in adolescents. - Moderation of the association of cIMT with gestational age by a composite lifestyle score, VO2peak and a cardiovascular risk score (BMI, blood pressure, HbA1c, lipid profile, triglycerides) in adolescents. | — |
Countries
Germany
Contacts
Public ContactKarsten Königstein
Universitätskinderklinik
Outcome results
None listed