Does a measurable decrease in bioavailable thiamine (vitamin B1) occur during the course of surgery performed with cardiopulmonary bypass (CPB)?

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00039980

Enrollment

Registered

2026-04-27

Start date

2020-12-01

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E51

Interventions

Group 1: Infants and children under three years of age undergoing cardiac surgery with the use of cardiopulmonary bypass. Serum thiamine levels will be measured at predefined time points. Two analytic

Eligibility

Sex/Gender

All

Age

No minimum to 3 Years

Inclusion criteria

Inclusion criteria: Cardio-Pulmonary-Bypass Heartsurgery

Exclusion criteria

Exclusion criteria: Known Thiamindeficiency Inborn Metabolic defect

Design outcomes

Primary

Measure	Time frame
Thiamine blood levels (comparison of both measurement methods) measured preoperatively, at the initiation of cardiopulmonary bypass (CPB), postoperatively, and daily for an additional three days postoperatively. Blood sampling was performed at time points coinciding with routine clinical blood draws, and analysis was carried out using high-performance liquid chromatography (HPLC) and a functional microbiological assay (ID-Vit®). Blood sampling: 1: Prior to the start of surgery, at the time of venous access placement 2: After 50% of the cardiopulmonary bypass (CPB) duration 3: Upon admission to the intensive care unit (ICU) postoperatively 4: Six hours after admission 5: The following morning at 6:00 a.m. 6: After an additional 24 hours 7: After a further 24 hours	—

Measure

Time frame

Thiamine blood levels (comparison of both measurement methods) measured preoperatively, at the initiation of cardiopulmonary bypass (CPB), postoperatively, and daily for an additional three days postoperatively. Blood sampling was performed at time points coinciding with routine clinical blood draws, and analysis was carried out using high-performance liquid chromatography (HPLC) and a functional microbiological assay (ID-Vit®). Blood sampling: 1: Prior to the start of surgery, at the time of venous access placement 2: After 50% of the cardiopulmonary bypass (CPB) duration 3: Upon admission to the intensive care unit (ICU) postoperatively 4: Six hours after admission 5: The following morning at 6:00 a.m. 6: After an additional 24 hours 7: After a further 24 hours

—

Countries

Germany

Contacts

Public ContactNikolaus Haas

LMU Klinikum Kinderkardiologie

Nikolaus.Haas@med.uni-muenchen.de+49 (0) 89-4400-73941

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026