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Pagetoid reticulosis and its differential diagnoses: a multicenter, retrospective, non-interventional study describing the histological and clinical criteria

Pagetoid reticulosis and its differential diagnoses: a multicenter, retrospective, non-interventional study describing the histological and clinical criteria - PagRet

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00039944
Enrollment
50
Registered
2026-04-15
Start date
2025-09-30
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C84.0

Interventions

Group 1: This is a multicenter study. Diagnostic slides and formalin-fixed, paraffin-embedded tissue samples from representative lesions of patients with Paget-like reticulosis will be retrieved from

Sponsors

Charité-Universitätsklinikum Berlin
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Adult patients for whom skin tissue samples are archived at the respective participating center. - Lymphoproliferative disease of the skin with histologically evident so-called “Pagetoid” epidermotropism, as is typical of Pagetoid reticulosis. In addition to Pagetoid reticulosis, the following entities in particular are considered and included: Mycosis fungoides, lymphomatoid papulosis type D, primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma, primary cutaneous gamma-delta T-cell lymphoma, primary cutaneous peripheral T-cell lymphoma NOS - The diagnosis must be confirmed by clinical-pathological correlation, and the course of the disease must be traceable for at least 6 months

Exclusion criteria

Exclusion criteria: Patients under the age of 18

Design outcomes

Primary

MeasureTime frame
A summary of cases of pagetoid reticulosis and their histological and clinical characteristics, compared with histological differential diagnoses, to expand knowledge of this very rare disease.

Secondary

MeasureTime frame
Identification of clinical and histological criteria for the diagnosis of “Pagetoid reticulosis”.

Countries

Germany, Switzerland

Contacts

Public ContactRose Moritz

Charité-Universitätsmedizin Berlin

rose.moritz@charite.de030450618518041

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026