Hemodynamics and mesenteric vEnous marKers in sepsis-associated colonic ischemia: Towards optimized Operative strategy

Hemodynamics and mesenteric vEnous marKers in sepsis-associated colonic ischemia: Towards optimized Operative strategy - HEKTOR

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00039901

Enrollment

Registered

2026-04-22

Start date

2026-05-04

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis-associated colonic ischemia

Interventions

Group 1: Patients undergoing a partial colectomy due to sepsis-associated colonic ischemia. During surgery, simultaneous sampling of arterial, central venous, and mesenteric venous blood is performed.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Sepsis-3 criteria fullfilled Patient needs an emergency (partial) colectomy informed consent

Exclusion criteria

Exclusion criteria: withdraw of informed consent Inability to collect blood from the relevant mesenteric vein. primary colonic diseases (e.g. Colitis ulcerosa, M. crohn) Acute Mesenteric ischemia with occlusion of Truncus coeliacus, superior/inferior mesenteric arterie

Design outcomes

Primary

Measure	Time frame
1. 30-day difference in mortality between the groups 2. Need for subsequent colonic resection	—

Secondary

Measure	Time frame
1. Incidence of postoperative complications (e.g., anastomotic leakage, stoma creation, secondary infections). 2. Duration of mechanical ventilation, length of stay in the ICU, and length of hospital stay depending on phenotypes 3. Association of mesenteric venous markers (pv, mesCO2–paCO2 gap, ?-lactate, local O2 extraction, respiratory quotient) with the primary endpoint. 4. Exploratory validation of DO2I cutoff values as risk markers for the development of mesenteric ischemia in the septic control cohort without initial colonic ischemia. 5. Descriptive analysis of additional biomarkers (I-FABP, D-lactate, citrulline, IL-6) from mesenteric venous blood regarding their association with enterocyte damage and outcome. 6. Faster detection of relevant bacteria in mesenteric venous blood compared to central venous blood	—

Measure

Time frame

1. Incidence of postoperative complications (e.g., anastomotic leakage, stoma creation, secondary infections). 2. Duration of mechanical ventilation, length of stay in the ICU, and length of hospital stay depending on phenotypes 3. Association of mesenteric venous markers (pv, mesCO2–paCO2 gap, ?-lactate, local O2 extraction, respiratory quotient) with the primary endpoint. 4. Exploratory validation of DO2I cutoff values as risk markers for the development of mesenteric ischemia in the septic control cohort without initial colonic ischemia. 5. Descriptive analysis of additional biomarkers (I-FABP, D-lactate, citrulline, IL-6) from mesenteric venous blood regarding their association with enterocyte damage and outcome. 6. Faster detection of relevant bacteria in mesenteric venous blood compared to central venous blood

—

Countries

Germany

Contacts

Public ContactMaximilian Möller

Universitätsklinikum Heidelberg – UK Mannheim GmbH

maximilian.moeller@umm.de+496213834454

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026