D66 D67
Conditions
Interventions
Group 1: Sonographic parameters of the elbow, knee, and ankle joints of persons with haemophilia are assessed in multiple imaging planes. Morphological changes of the synovial membrane, bone, and cart
Sponsors
Bergische Universität Wuppertal
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients: Adult patients with hemophilia A or B Control subjects: Adult male and healthy subjects who do not have any blood coagulation disorder
Exclusion criteria
Exclusion criteria: Patients: Acute injuries or joint hemorrhages, other coagulation disorders (e.g., von Willebrand syndrome), neurological disorders, diagnosed cognitive impairments Control subjects: Blood clotting disorders, rheumatic diseases, acute injuries/previous surgeries/joint replacement of the elbow, knee, or ankle joints, diagnosed cognitive impairments
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Description of sonographic parameters of the surrounding structures of the knee, elbow, and ankle joints, and determination of the relationship with the concentration of various cytokines in venous blood. The following parameters are used: - Morphological alterations - Power Doppler examination - Cytokine concentration in venous blood determined by membrane-based antibody array. | — |
Secondary
| Measure | Time frame |
|---|---|
| Stiffness of intraarticular tissue measured using shear-wave elastography | — |
Countries
Germany
Contacts
Public ContactFabian Tomschi
Lehrstuhl für Sportmedizin Bergische Universität Wuppertal
Outcome results
None listed