Studies on the value of the calcium stimulation test in the diagnosis of medullary thyroid carcinoma in contrast to C-cell hyperplasia

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00039813

Enrollment

221

Registered

2026-04-01

Start date

2026-03-24

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Calcitonin elevation E04.1 E04.2

Interventions

Group 1: Retrospective analysis of patients with elevated basal calcitonin levels who underwent a calcium stimulation test followed by thyroidectomy. The following data will be collected: - Basal calc

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Patients with elevated calcitonin - Patients who have undergone a calcium stimulation test - Available histopathological examination following thyroid surgery - Complete clinical records

Exclusion criteria

Exclusion criteria: - Incomplete datasets - Lack of histopathological correlation

Design outcomes

Primary

Measure	Time frame
Sensitivity, specificity, positive and negative predictive value of the calcium stimulation test. Sensitivity, specificity, positive predictive value, and negative predictive value will be calculated by comparing the results of the calcium stimulation test (index test; peak calcitonin after calcium administration) with the histopathological diagnosis after thyroidectomy as the reference standard (medullary thyroid carcinoma vs. C-cell hyperplasia or no MTC). The analysis will be performed retrospectively after availability of both datasets. The calcium stimulation test was performed preoperatively, and the reference standard (histopathology) was obtained postoperatively.	—

Measure

Time frame

Sensitivity, specificity, positive and negative predictive value of the calcium stimulation test. Sensitivity, specificity, positive predictive value, and negative predictive value will be calculated by comparing the results of the calcium stimulation test (index test; peak calcitonin after calcium administration) with the histopathological diagnosis after thyroidectomy as the reference standard (medullary thyroid carcinoma vs. C-cell hyperplasia or no MTC). The analysis will be performed retrospectively after availability of both datasets. The calcium stimulation test was performed preoperatively, and the reference standard (histopathology) was obtained postoperatively.

—

Secondary

Measure	Time frame
Establishing cut-off values ??for recommending thyroidectomy in cases of elevated calcitonin levels	—

Countries

Germany

Contacts

Public ContactBarbara Kreppel

Klinik und Poliklinik für Nuklearmedizin, Uniklinik Bonn

barbara.kreppel@ukbonn.de004922828715181

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026