Retrospective analysis comparing conventional sternotomy-based thymectomy and minimally invasive VATS thymectomy.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00039714

Enrollment

200

Registered

2026-03-25

Start date

2026-07-01

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

D15.0 G70.0

Interventions

Group 1: Patients who underwent minimally invasive thymectomy (video-assisted thoracoscopic surgery, VATS) for myasthenia gravis and/or thymoma. Data collected include demographic characteristics, per

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who have undergone thymectomies, VATS thymectomies, conventional/open thymectomies, those with myasthenia gravis, thymoma/thymic pathology; complete clinical data available; available clinical follow-up data

Exclusion criteria

Exclusion criteria: Incomplete data sets, revision surgeries, emergency surgeries, combined procedures, no available clinical follow-up data

Design outcomes

Primary

Measure	Time frame
The following outcomes will be studied from January 1, 2005, to December 31, 2025: 1. Diagnostic yield of thymectomy - Proportion of thymectomies leading to a definitive histopathological diagnosis; assessed after histopathological evaluation. 2. Impact an therapeutic management - Proportion of cases in wich the results of thymectomy led to a change in patient management; assessed after case review/ therapy decision.	—

Measure

Time frame

The following outcomes will be studied from January 1, 2005, to December 31, 2025: 1. Diagnostic yield of thymectomy - Proportion of thymectomies leading to a definitive histopathological diagnosis; assessed after histopathological evaluation. 2. Impact an therapeutic management - Proportion of cases in wich the results of thymectomy led to a change in patient management; assessed after case review/ therapy decision.

—

Secondary

Measure	Time frame
1. Concordance between preoperative imaging and histopathology - Comparison of preoperative imaging with histopathological findings; assessed after surgery and pathology evaluation. 2. Operative safety profile -Perioperative complications, blood loss, and operative duration; assessed perioperatively until hospital discharge. 3. Comparison of surgical approaches - VATS vs. open thymectomy regarding clinical outcomes; assessed after surgery. 4. Patient- and disease-related predictors for quality of care - Influence of patient and disease characteristics on clinical outcomes; assessed retrospectively from available data. 5. Time intervals - Intervals between diagnosis, surgery, and changes in therapy; assessed retrospectively from hospital records and follow-up documentations.	—

Measure

Time frame

1. Concordance between preoperative imaging and histopathology - Comparison of preoperative imaging with histopathological findings; assessed after surgery and pathology evaluation. 2. Operative safety profile -Perioperative complications, blood loss, and operative duration; assessed perioperatively until hospital discharge. 3. Comparison of surgical approaches - VATS vs. open thymectomy regarding clinical outcomes; assessed after surgery. 4. Patient- and disease-related predictors for quality of care - Influence of patient and disease characteristics on clinical outcomes; assessed retrospectively from available data. 5. Time intervals - Intervals between diagnosis, surgery, and changes in therapy; assessed retrospectively from hospital records and follow-up documentations.

—

Countries

Germany

Contacts

Public ContactJohannes Greven

Klinik für Thoraxchirurgie, Uniklinik Aachen

jgreven@ukaachen.de0241 80-38272

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 29, 2026