I50
Conditions
Interventions
Group 1: Heart failure cohort
Patients with heart failure and indication for initiation or modification of therapy.
Two study visits (before and after therapy change) including: medical history and ph
Sponsors
Universitätsklinikum Leipzig
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Ability to provide informed consent and written consent to participate Cohort-specific criteria: Heart failure cohort: Diagnosed heart failure with indication for initiation or modification of therapy Arrhythmia cohort: Diagnosed clinically relevant cardiac arrhythmia (e.g. atrial fibrillation) requiring treatment Valvular heart disease cohort: Diagnosed clinically relevant valvular heart disease with planned interventional or surgical treatment Control cohort: Cardiovascularly healthy individuals without known manifest atherosclerosis, heart failure, relevant valvular disease, or clinically relevant arrhythmias
Exclusion criteria
Exclusion criteria: Inability to provide informed consent Pregnancy or breastfeeding Requirement for inpatient treatment due to conditions other than the qualifying disease Weight change > 5 kg or > 5% of body weight within the last 3 months Food allergies or intolerances Vegan or vegetarian diet Alcohol or drug abuse Claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour energy expenditure (24-h EE), measured using indirect calorimetry in a whole-room indirect calorimeter, Time points: before initiation/modification of therapy (T1) and after therapy (T2), Method: continuous measurement of oxygen consumption (VO2) and carbon dioxide production (VCO2) over 24 hours to calculate energy expenditure. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Resting energy expenditure (REE), energy expenditure during sleep and physical activity, Time points: T1 (before therapy) and T2 (after therapy), Method: indirect calorimetry (whole-room calorimeter and standardized measurement procedures). 2. Anthropometric parameters (age, height, weight, body mass index [BMI], body roundness index, body composition), Time points: T1 and T2, Method: standardized physical examination, bioelectrical impedance analysis (BIA), and BodPod assessment. 3. Echocardiographic parameters (e.g. left ventricular ejection fraction, strain analysis, myocardial work, diastolic function [E/e’, E/A], systolic pulmonary artery pressure), Time points: T1 and T2, Method: transthoracic echocardiography. 4. Metabolic and molecular parameters (e.g. fatty acid oxidation, glucose utilization, markers of systemic inflammation), Time points: T1 and T2, Method: blood sampling followed by routine laboratory analyses and exploratory proteomics (e.g. OLINK cardiometabolic panel and metabolite profiling). | — |
Countries
Germany
Contacts
Public ContactAlexander Kogel
Universitätsklinikum Leipzig, Klinik und Poliklinik für Kardiologie
Outcome results
None listed